Zinc deficiency as severity predictor in pediatric dengue viral infection: a meta-analysis

Firyal Nadiah Rahmah, Salsabila Nabilah Rifdah, Ricky Indra Alfaray, Andry Gonius, Sugeng Soegijanto

Research output: Contribution to journalArticlepeer-review


Background: Endothelial cells in dengue viral infection (DVI) produce Tumor Necrosis Factor (TNF-α) in abundant number from zinc deficient patients rather than non deficient. This finding suggest zinc is protective for maintenance of endothelial cell, thus decrease the severity of dengue viral infection. Aim: In this meta-analysis, we will compare the zinc serum in deficient and non deficientpatients from several studies as predictor in dengue viral infection. Methods: We included all research articles in pediatric patients diagnosed with Dengue Fever or Dengue Hemorrhagic Fever with information on zinc serum available. Zinc deficiency is reported to be below 9,18 µmol/LThe severity is divided into dengue fever against dengue hemorrhagic fever. Result: There were 217 patients included in this study. The meta-analysis showed that there are significant difference in both results (OR 6.32 [3.50 - 11.40], p = 0.0003; I2: 84%, p < 0.00001). Conclusion: Zinc deficiency in pediatric dengue viral infection can be used for the predictor of severityin dengue viral infection. Zinc supplementation can be mandatory for dengue viral infection treatment

Original languageEnglish
Pages (from-to)1568-1570
Number of pages3
JournalPakistan Journal of Medical and Health Sciences
Issue number4
Publication statusPublished - Oct 2020


  • Dengue fever
  • Dengue hemorrhagic fever
  • Dengue viral infection
  • Zinc deficiency


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