TY - JOUR
T1 - Xanthine Oxidase Inhibitory Activity of Xanthones from Calophyllum pseudomole P. F. Stevens
AU - Saputri, Ratih D.
AU - Tukiran,
AU - Suyatno,
AU - A.wati, First
AU - Dzulkarnain, Shod A.
AU - Zakiyah, Mufidatuz
AU - Tjahjandarie, Tjitjik S.
AU - Tanjung, Mulyadi
N1 - Publisher Copyright:
© 2024 Saputri et al.
PY - 2024/2/1
Y1 - 2024/2/1
N2 - The genus Calophyllum (Calophyllaceae) is a plant proven to produce various xanthones, chromanoic acids, and 4-phenyl coumarins. This study aims to determine the xanthine oxidase inhibitory activity of xanthones from Calophylum pseudomole P.F. Stevens. Two xanthones, ananixanthone (1) and caloxanthone L (2), were isolated from Calophyllum pseudomole stem barks. The structures of both xanthones were determined based on UV, HRESI-MS, 1D, and 2D NMR spectral data. Compounds 1-2 showed xanthine oxidase inhibitory activity with an IC50 of 15.05 and 17.7 μM, respectively, and were categorized as potent.
AB - The genus Calophyllum (Calophyllaceae) is a plant proven to produce various xanthones, chromanoic acids, and 4-phenyl coumarins. This study aims to determine the xanthine oxidase inhibitory activity of xanthones from Calophylum pseudomole P.F. Stevens. Two xanthones, ananixanthone (1) and caloxanthone L (2), were isolated from Calophyllum pseudomole stem barks. The structures of both xanthones were determined based on UV, HRESI-MS, 1D, and 2D NMR spectral data. Compounds 1-2 showed xanthine oxidase inhibitory activity with an IC50 of 15.05 and 17.7 μM, respectively, and were categorized as potent.
KW - ananixanthone
KW - Calophyllum pseudomole
KW - caloxanthone L
KW - xanthin eoxidase
KW - xanthone
UR - http://www.scopus.com/inward/record.url?scp=85184676673&partnerID=8YFLogxK
U2 - 10.26538/tjnpr/v8i1.31
DO - 10.26538/tjnpr/v8i1.31
M3 - Article
AN - SCOPUS:85184676673
SN - 2616-0684
VL - 8
SP - 5932
EP - 5935
JO - Tropical Journal of Natural Product Research
JF - Tropical Journal of Natural Product Research
IS - 1
ER -