Voacalgines A-E, new indole alkaloids from Voacanga grandifolia

Yusuke Hirasawa; Hiroko Arai; Abdul Rahman; Idha Kusumawati; Noor Cholies Zaini; Osamu Shirota; Hiroshi Morita

doi:10.1016/j.tet.2013.10.097

Voacalgines A-E, new indole alkaloids from Voacanga grandifolia

Yusuke Hirasawa, Hiroko Arai, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Osamu Shirota, Hiroshi Morita

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Five new indole alkaloids, voacalgines A-E (1-5) consisting of a C-mavacurine type of skeleton with 2,3-dihydroxybenzoate moiety, a macroline-type of skeleton, or a macroline-type of skeleton with C₆ unit, were isolated from the bark of Voacanga grandifolia. Their relative structures were determined by means of NMR data. Voacalgine A showed moderate cell growth inhibitory activities against HL-60 and HCT116 cells.

Original language	English
Pages (from-to)	10869-10875
Number of pages	7
Journal	Tetrahedron
Volume	69
Issue number	51
DOIs	https://doi.org/10.1016/j.tet.2013.10.097
Publication status	Published - 23 Dec 2013

Keywords

Cytotoxicity
Indole alkaloid
Voacalgine A
Voacanga grandifolia

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10.1016/j.tet.2013.10.097

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title = "Voacalgines A-E, new indole alkaloids from Voacanga grandifolia",

abstract = "Five new indole alkaloids, voacalgines A-E (1-5) consisting of a C-mavacurine type of skeleton with 2,3-dihydroxybenzoate moiety, a macroline-type of skeleton, or a macroline-type of skeleton with C6 unit, were isolated from the bark of Voacanga grandifolia. Their relative structures were determined by means of NMR data. Voacalgine A showed moderate cell growth inhibitory activities against HL-60 and HCT116 cells.",

keywords = "Cytotoxicity, Indole alkaloid, Voacalgine A, Voacanga grandifolia",

author = "Yusuke Hirasawa and Hiroko Arai and Abdul Rahman and Idha Kusumawati and Zaini, {Noor Cholies} and Osamu Shirota and Hiroshi Morita",

note = "Funding Information: This work was supported by Grants-in-Aid for Scientific Research from Japan Society for the Promotion of Science, The Open Research Center Project, and Takeda Science Foundation. ",

year = "2013",

month = dec,

day = "23",

doi = "10.1016/j.tet.2013.10.097",

language = "English",

volume = "69",

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journal = "Tetrahedron",

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T1 - Voacalgines A-E, new indole alkaloids from Voacanga grandifolia

AU - Hirasawa, Yusuke

AU - Arai, Hiroko

AU - Rahman, Abdul

AU - Kusumawati, Idha

AU - Zaini, Noor Cholies

AU - Shirota, Osamu

AU - Morita, Hiroshi

N1 - Funding Information: This work was supported by Grants-in-Aid for Scientific Research from Japan Society for the Promotion of Science, The Open Research Center Project, and Takeda Science Foundation.

PY - 2013/12/23

Y1 - 2013/12/23

N2 - Five new indole alkaloids, voacalgines A-E (1-5) consisting of a C-mavacurine type of skeleton with 2,3-dihydroxybenzoate moiety, a macroline-type of skeleton, or a macroline-type of skeleton with C6 unit, were isolated from the bark of Voacanga grandifolia. Their relative structures were determined by means of NMR data. Voacalgine A showed moderate cell growth inhibitory activities against HL-60 and HCT116 cells.

AB - Five new indole alkaloids, voacalgines A-E (1-5) consisting of a C-mavacurine type of skeleton with 2,3-dihydroxybenzoate moiety, a macroline-type of skeleton, or a macroline-type of skeleton with C6 unit, were isolated from the bark of Voacanga grandifolia. Their relative structures were determined by means of NMR data. Voacalgine A showed moderate cell growth inhibitory activities against HL-60 and HCT116 cells.

KW - Cytotoxicity

KW - Indole alkaloid

KW - Voacalgine A

KW - Voacanga grandifolia

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DO - 10.1016/j.tet.2013.10.097

M3 - Article

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VL - 69

SP - 10869

EP - 10875

JO - Tetrahedron

JF - Tetrahedron

IS - 51

ER -

Voacalgines A-E, new indole alkaloids from Voacanga grandifolia

Abstract

Keywords

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