Voacalgines A-E, new indole alkaloids from Voacanga grandifolia

Yusuke Hirasawa, Hiroko Arai, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Osamu Shirota, Hiroshi Morita

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Five new indole alkaloids, voacalgines A-E (1-5) consisting of a C-mavacurine type of skeleton with 2,3-dihydroxybenzoate moiety, a macroline-type of skeleton, or a macroline-type of skeleton with C6 unit, were isolated from the bark of Voacanga grandifolia. Their relative structures were determined by means of NMR data. Voacalgine A showed moderate cell growth inhibitory activities against HL-60 and HCT116 cells.

Original languageEnglish
Pages (from-to)10869-10875
Number of pages7
JournalTetrahedron
Volume69
Issue number51
DOIs
Publication statusPublished - 23 Dec 2013

Keywords

  • Cytotoxicity
  • Indole alkaloid
  • Voacalgine A
  • Voacanga grandifolia

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