Vitamin and mineral supplementation for β-thalassemia during COVID-19 pandemic

Annette D'Arqom, Melvanda G. Putri, Yovani Savitri, Andi Muh Rahul Alfaidin

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


Aim: Low levels of immune-related micronutrients have been identified in β-thalassemia samples. Moreover, the excess amount of iron, contributing to oxidative stress in the pathogenesis of the disease, alters the immune system in β-thalassemia, which is important during the COVID-19 pandemic. Materials & Methods: Searches of PUBMED and EMBASE were conducted to identify the level and supplementation of micronutrients in β-thalassemia, published from 2001-May 2020. Results: The review found six observational and five interventional studies supporting the importance of supplementing vitamins and minerals among patients with β-thalassemia. Conclusion: Supplementation of immune-related vitamins and minerals might bring benefits to the immune system, especially in reducing oxidative stress in β-thalassemia. Nutrition is important for the human body, including the immune system. During COVID-19, maintaining immunity is crucial to prevent transmission, because vaccines remain under development and definitive therapy is under clinical trial. In β-thalassemia, for which immune-related vitamins and minerals are inadequate, supplementation is important, not only to boost the immune system during this outbreak but also to maintain other body functions.

Original languageEnglish
Article number0110
JournalFuture Science OA
Issue number9
Publication statusPublished - Oct 2020


  • SARS-CoV-2
  • ascorbic acid
  • cholecalciferol
  • good health and well being
  • immunity
  • selenium
  • tocopherol
  • zinc


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