Viral load in Indonesian patients with chronic liver disease and in blood donors infected with different subtypes of hepatitis C virus

Maria I. Lusida; Retno Handajani; Chairul A. Nidom; Soemarto; Siswanto Darmadi; Pangestu Adi; Motoko Fujii; Tsunenori Fujita; Satoshi Ishido; Hak Hotta

Viral load in Indonesian patients with chronic liver disease and in blood donors infected with different subtypes of hepatitis C virus

Maria I. Lusida, Soetjipto, Retno Handajani, Chairul A. Nidom, Soemarto, Siswanto Darmadi, Pangestu Adi, Motoko Fujii, Tsunenori Fujita, Satoshi Ishido, Hak Hotta

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Abstract

The viral load of different hepatitis C virus (HCV) subtypes, including the globally distributed HCV-1b and the unique Indonesian subtype HCV-1c, was analyzed using serum samples obtained from Indonesian blood donors and patients with chronic liver disease. The mean viral load of HCV-1c was comparable with that of HCV-1b, suggesting that HCV-1c is as pathogenic as HCV-1b. On the other hand, the mean viral load of HCV-2a was lower than that of HCV-1b or HCV-1c, with this results being consistent with previous observations. Interestingly, some HCV-2a strains were associated with a high viral load that was almost equivalent to that of HCV-1b and HCV-1c. This result implies the possibility that there exists a minor fraction of HCV-2a strains that cause higher levels of viremia compared with the majority of ordinary HCV-2a strains.

Original language	English
Pages (from-to)	67-69
Number of pages	3
Journal	Japanese Journal of Infectious Diseases
Volume	53
Issue number	2
Publication status	Published - Apr 2000

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title = "Viral load in Indonesian patients with chronic liver disease and in blood donors infected with different subtypes of hepatitis C virus",

abstract = "The viral load of different hepatitis C virus (HCV) subtypes, including the globally distributed HCV-1b and the unique Indonesian subtype HCV-1c, was analyzed using serum samples obtained from Indonesian blood donors and patients with chronic liver disease. The mean viral load of HCV-1c was comparable with that of HCV-1b, suggesting that HCV-1c is as pathogenic as HCV-1b. On the other hand, the mean viral load of HCV-2a was lower than that of HCV-1b or HCV-1c, with this results being consistent with previous observations. Interestingly, some HCV-2a strains were associated with a high viral load that was almost equivalent to that of HCV-1b and HCV-1c. This result implies the possibility that there exists a minor fraction of HCV-2a strains that cause higher levels of viremia compared with the majority of ordinary HCV-2a strains.",

author = "Lusida, {Maria I.} and Soetjipto and Retno Handajani and Nidom, {Chairul A.} and Soemarto and Siswanto Darmadi and Pangestu Adi and Motoko Fujii and Tsunenori Fujita and Satoshi Ishido and Hak Hotta",

year = "2000",

month = apr,

language = "English",

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pages = "67--69",

journal = "Japanese Journal of Infectious Diseases",

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TY - JOUR

T1 - Viral load in Indonesian patients with chronic liver disease and in blood donors infected with different subtypes of hepatitis C virus

AU - Lusida, Maria I.

AU - Soetjipto,

AU - Handajani, Retno

AU - Nidom, Chairul A.

AU - Soemarto,

AU - Darmadi, Siswanto

AU - Adi, Pangestu

AU - Fujii, Motoko

AU - Fujita, Tsunenori

AU - Ishido, Satoshi

AU - Hotta, Hak

PY - 2000/4

Y1 - 2000/4

N2 - The viral load of different hepatitis C virus (HCV) subtypes, including the globally distributed HCV-1b and the unique Indonesian subtype HCV-1c, was analyzed using serum samples obtained from Indonesian blood donors and patients with chronic liver disease. The mean viral load of HCV-1c was comparable with that of HCV-1b, suggesting that HCV-1c is as pathogenic as HCV-1b. On the other hand, the mean viral load of HCV-2a was lower than that of HCV-1b or HCV-1c, with this results being consistent with previous observations. Interestingly, some HCV-2a strains were associated with a high viral load that was almost equivalent to that of HCV-1b and HCV-1c. This result implies the possibility that there exists a minor fraction of HCV-2a strains that cause higher levels of viremia compared with the majority of ordinary HCV-2a strains.

AB - The viral load of different hepatitis C virus (HCV) subtypes, including the globally distributed HCV-1b and the unique Indonesian subtype HCV-1c, was analyzed using serum samples obtained from Indonesian blood donors and patients with chronic liver disease. The mean viral load of HCV-1c was comparable with that of HCV-1b, suggesting that HCV-1c is as pathogenic as HCV-1b. On the other hand, the mean viral load of HCV-2a was lower than that of HCV-1b or HCV-1c, with this results being consistent with previous observations. Interestingly, some HCV-2a strains were associated with a high viral load that was almost equivalent to that of HCV-1b and HCV-1c. This result implies the possibility that there exists a minor fraction of HCV-2a strains that cause higher levels of viremia compared with the majority of ordinary HCV-2a strains.

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M3 - Article

C2 - 10871917

AN - SCOPUS:0033940675

SN - 1344-6304

VL - 53

SP - 67

EP - 69

JO - Japanese Journal of Infectious Diseases

JF - Japanese Journal of Infectious Diseases

IS - 2

ER -

Viral load in Indonesian patients with chronic liver disease and in blood donors infected with different subtypes of hepatitis C virus

Abstract

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