Usefulness of Measuring Serum Amyloid A Concentration in Japanese Black Cattle in Clinical Practice

Urara Shinya, Osamu Yamato, Yuka Iwamura, Tomohiro Kato, Yuhei Hamada, Oky Setyo Widodo, Masayasu Taniguchi, Mitsuhiro Takagi

Research output: Contribution to journalArticlepeer-review


This study investigated the concentration of serum amyloid A (SAA), an acute phase protein, in Japanese Black cattle. Four practical trials were performed to evaluate the transition of SAA and sialic acid before and after dehorning, the relationship between the SAA concentration and other blood test parameters, the SAA dynamics in the diseased cattle, and the blood test results, including the SAA concentrations, of the two cases with a follow-up. The SAA concentration increased with dehorning but decreased 7 days after dehorning. The SAA concentration is positively correlated with the α-globulin, sialic acid, and fibrinogen concentrations and negatively correlated with the serum iron concentration. The SAA concentration in the deceased herd was significantly higher than that in the cured outcome herd. In addition, the SAA concentration in the cured group decreased significantly from the first test to retesting but increased significantly in the disuse group. Thus, SAA is a sensitive index of inflammation and a monitoring tool in Japanese Black cattle, and its measurement is considered useful in clinical practice.

Original languageEnglish
Article number528
JournalVeterinary Sciences
Issue number8
Publication statusPublished - Aug 2023


  • Japanese Black
  • acute phase protein
  • diagnosis
  • inflammatory marker
  • serum amyloid A


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