TY - JOUR
T1 - Urease Levels and Gastritis Stage in Dyspeptic Patients
AU - Miftahussurur, Muhammad
AU - Putri, Chyntia Dewi Maharani
AU - Sugihartono, Titong
AU - Syam, Ari Fahrial
AU - Purbayu, Herry
AU - Priyantini, Diah
AU - Kahar, Hartono
AU - Rezkitha, Yudith Annisa Ayu
AU - Nusi, Iswan Abbas
AU - Setiawan, Poernomo Boedi
AU - Maimunah, Ummi
AU - Waskito, Langgeng Agung
AU - Kholili, Ulfa
AU - Widodo, Budi
AU - Vidyani, Amie
AU - Thamrin, Husin
AU - Siregar, Gontar A.
AU - I’tishom, Reny
AU - Uchida, Tomohisa
AU - Yamaoka, Yoshio
N1 - Publisher Copyright:
© 2022, Indonesian Society of Internal Medicine. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Background: Dyspepsia is a frequent main symptom of inpatients and outpatients scenario in Indonesia. However, the number of endoscopy facilities are still low, thus the use of non-invasive method to detect gastritis is necessary. We measured the relationship between urease levels and the stage of gastritis in dyspeptic adult patients. Methods: A cross-sectional study included outpatient dyspepsia patient from November 2018 to February 2019. We examined14C-Urea Breath Test (UBT) and determined the stage of gastritis based on the Updated Sydney System classification. Results: The urease level of acute and chronic gastritis positive patients were higher than negative patients (p = 0.001, r = 0.353; p <0.0001, r = 0.433, respectively). The AUC value of14C-UBT to detect acute, chronic, and atrophic gastritis are 0.889, 0.632 and 0.544, respectively. The best cut-off points of14C-UBT to predict acute gastritis was ≥26.50δ‰ with sensitivity and specificity being 88.89% and 63.95%, respectively. Whereas the best cut-off points for chronic gastritis was ≥34.50δ‰ with 82.89% sensitivity, 63.16% specificity. As for atrophic gastritis, it showed very low AUC value, hence it is not a sufficient test modality to predict atrophic gastritis cases. Conclusion:14C-UBT is sufficient for predicting acute or chronic gastritis but not for atrophic gastritis.
AB - Background: Dyspepsia is a frequent main symptom of inpatients and outpatients scenario in Indonesia. However, the number of endoscopy facilities are still low, thus the use of non-invasive method to detect gastritis is necessary. We measured the relationship between urease levels and the stage of gastritis in dyspeptic adult patients. Methods: A cross-sectional study included outpatient dyspepsia patient from November 2018 to February 2019. We examined14C-Urea Breath Test (UBT) and determined the stage of gastritis based on the Updated Sydney System classification. Results: The urease level of acute and chronic gastritis positive patients were higher than negative patients (p = 0.001, r = 0.353; p <0.0001, r = 0.433, respectively). The AUC value of14C-UBT to detect acute, chronic, and atrophic gastritis are 0.889, 0.632 and 0.544, respectively. The best cut-off points of14C-UBT to predict acute gastritis was ≥26.50δ‰ with sensitivity and specificity being 88.89% and 63.95%, respectively. Whereas the best cut-off points for chronic gastritis was ≥34.50δ‰ with 82.89% sensitivity, 63.16% specificity. As for atrophic gastritis, it showed very low AUC value, hence it is not a sufficient test modality to predict atrophic gastritis cases. Conclusion:14C-UBT is sufficient for predicting acute or chronic gastritis but not for atrophic gastritis.
KW - Dyspepsia
KW - cancer
KW - gastritis severity
KW - urea breath test
UR - http://www.scopus.com/inward/record.url?scp=85127927276&partnerID=8YFLogxK
M3 - Article
C2 - 35398825
AN - SCOPUS:85127927276
SN - 0125-9326
VL - 54
SP - 42
EP - 51
JO - Acta medica Indonesiana
JF - Acta medica Indonesiana
IS - 1
ER -