Unlocking the impact of translocated promoter region (TPR) on autophagy and cancer progression

Translocated promoter region (TPR) serves as a crucial component within the nuclear pore complex (NPC), situated in the nuclear basket region. Initially identified through the TPR-Met oncogene fusion, TPR exhibits a diverse array of cellular functions encompassing nucleocytoplasmic transport, transcriptional regulation, mitosis, and autophagy. Notably, recent research has underscored TPR’s significance in oncogenesis across various cancer types, such as ependymoma, cervical, and colorectal cancer. In this discourse, we provide an overview of TPR’s multifaceted roles and explore its implications in carcinogenesis, with a particular focus on its involvement in autophagy and its association with cancer progression.