Type II Diabetes as the Main Risk Factor of Arterial Stiffness in Chronic Kidney Disease Patients

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Abstract

Chronic kidney disease (CKD) is frequently linked to an increased risk of cardiovascular disease. Diabetes, hypertension, dyslipidemia, and obesity are all traditional risk factors of cardiovascular disease in CKD. However, the contribution of each of the traditional risk factors to arterial stiffness is unknown. This was a correlational study with a cross-sectional design. This study included forty CKD patients from Universitas Airlangga Hospital Surabaya, between December 2019 until March 2020. Serum samples were used to measure laboratory parameters, and Doppler ultrasound was used to assess carotid-femoral Pulse Wave Velocity (cfPWV). Spearman's analysis was conducted to determine correlations between cf-PWV and e-GFR, HBA1C, serum creatinine, and cystatin-C. Mann-Whitney test was performed to determine the association between type II diabetes with cf-PWV. Significant results were continued with linear regression analysis model. There were significant correlations between cf-PWV and e-GFR, HBA1C, serum creatinine, and cystatin-C. HBA1C showed the most significant positive correlation with a moderate correlation coefficient (p = 0.000; r = 0.581). Patients with type II diabetes was associated with increased cf-PWV. Linear regression model also revealed that HBA1C and history of diabetes were significant predictors of increased cf-PWV in CKD patients (β= 0.400; p = 0.011 and β= 0.537; p = 0.000, respectively). We found a positive correlation between HBA1C and cf-PWV and association between type II diabetes and increased cf-PWV. This proved that type II diabetes, especially with high HBA1C, acted as a significant risk factor for predicting increased arterial stiffness in CKD patients.

Original languageEnglish
Title of host publicationICMHI 2022 - 2022 6th International Conference on Medical and Health Informatics
PublisherAssociation for Computing Machinery
Pages210-214
Number of pages5
ISBN (Electronic)9781450396301
DOIs
Publication statusPublished - 15 May 2022
Event6th International Conference on Medical and Health Informatics, ICMHI 2022 - Virtual, Online, Japan
Duration: 12 May 202215 May 2022

Publication series

NameACM International Conference Proceeding Series

Conference

Conference6th International Conference on Medical and Health Informatics, ICMHI 2022
Country/TerritoryJapan
CityVirtual, Online
Period12/05/2215/05/22

Keywords

  • Type II diabetes
  • arterial stiffness
  • cardiovascular disease
  • cf-PWV
  • chronic kidney disease

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