TY - JOUR
T1 - Two new flavonols from Macaranga inermis pax & K.Hoffm
AU - Tanjung, Mulyadi
AU - Tjahjandarie, Tjitjik Srie
AU - Aldin, Muhammad Fajar
AU - Mardhiyyah, Shola
AU - Saputri, Ratih Dewi
AU - Syah, Yana Maolana
AU - Ahmat, Norizan
N1 - Publisher Copyright:
© 2023 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023
Y1 - 2023
N2 - Four isoprenylated flavonols, including two new compounds, macainermisins A-B (1-2), and two known compounds, sinoflavonoid P (3), broussoflavonol F (4), were isolated from the leaves of Macaranga inermis. A combination of HRESIMS, UV, 1D, and 2D NMR spectra elucidated the structures of 1-2. Flavonols (1-4) were evaluated against three cancer cells. Compound 1 showed high cytotoxicity against WiDR with an IC50 value of 0.93 µM, and compound 2 was active towards HeLa and WiDR (IC50 values of 0.90 and 0.94 µM), and compound 3 showed high activity towards 4T1 and HeLa (IC50 values of 0.83 and 0.98 µM).
AB - Four isoprenylated flavonols, including two new compounds, macainermisins A-B (1-2), and two known compounds, sinoflavonoid P (3), broussoflavonol F (4), were isolated from the leaves of Macaranga inermis. A combination of HRESIMS, UV, 1D, and 2D NMR spectra elucidated the structures of 1-2. Flavonols (1-4) were evaluated against three cancer cells. Compound 1 showed high cytotoxicity against WiDR with an IC50 value of 0.93 µM, and compound 2 was active towards HeLa and WiDR (IC50 values of 0.90 and 0.94 µM), and compound 3 showed high activity towards 4T1 and HeLa (IC50 values of 0.83 and 0.98 µM).
KW - cytotoxic effects
KW - Euphorbiaceae
KW - flavonols
KW - macainermisins A-B
KW - Macaranga inermis
UR - http://www.scopus.com/inward/record.url?scp=85174606227&partnerID=8YFLogxK
U2 - 10.1080/14786419.2023.2272783
DO - 10.1080/14786419.2023.2272783
M3 - Article
AN - SCOPUS:85174606227
SN - 1478-6419
JO - Natural Product Research
JF - Natural Product Research
ER -
