Two new flavonols from Macaranga inermis pax & K.Hoffm

Mulyadi Tanjung, Tjitjik Srie Tjahjandarie, Muhammad Fajar Aldin, Shola Mardhiyyah, Ratih Dewi Saputri, Yana Maolana Syah, Norizan Ahmat

Research output: Contribution to journalArticlepeer-review

Abstract

Four isoprenylated flavonols, including two new compounds, macainermisins A-B (1-2), and two known compounds, sinoflavonoid P (3), broussoflavonol F (4), were isolated from the leaves of Macaranga inermis. A combination of HRESIMS, UV, 1D, and 2D NMR spectra elucidated the structures of 1-2. Flavonols (1-4) were evaluated against three cancer cells. Compound 1 showed high cytotoxicity against WiDR with an IC50 value of 0.93 µM, and compound 2 was active towards HeLa and WiDR (IC50 values of 0.90 and 0.94 µM), and compound 3 showed high activity towards 4T1 and HeLa (IC50 values of 0.83 and 0.98 µM).

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusAccepted/In press - 2023

Keywords

  • Euphorbiaceae
  • Macaranga inermis
  • cytotoxic effects
  • flavonols
  • macainermisins A-B

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