Two new chromanone acids from the stem bark of Calophyllum peekelii Lauterb

Tjitjik Srie Tjahjandarie, Wisnu Aji Setyo Nugroho, Hady Palgunadi, Ratih Dewi Saputri, Mulyadi Tanjung

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Three chromanone acids were isolated from the stem bark of Calophyllum peekelii Lauterb. Among them are two new chromanone acids, calopeekelioic acids A (1) and B (2), along with calolongic acid (3), Their structures were established by analyzing a combination of HRESIMS, 1 D, and 2 D NMR spectra. Chromanone acids 1-3 were evaluated for their antiplasmodial activity against Plasmodium falciparum strain 3D7. Compounds 1-2 showed high activity with an IC50 value of 1.70 and 1.01 µg/mL, respectively.

Original languageEnglish
Pages (from-to)3214-3219
Number of pages6
JournalNatural Product Research
Volume37
Issue number19
DOIs
Publication statusPublished - 2023

Keywords

  • Calopeekelioic acids A-B
  • Calophyllum peekelii
  • antiplasmodial
  • chromanone acid

Fingerprint

Dive into the research topics of 'Two new chromanone acids from the stem bark of Calophyllum peekelii Lauterb'. Together they form a unique fingerprint.

Cite this