TY - JOUR
T1 - Two new chromanone acids from the stem bark of Calophyllum peekelii Lauterb
AU - Tjahjandarie, Tjitjik Srie
AU - Nugroho, Wisnu Aji Setyo
AU - Palgunadi, Hady
AU - Saputri, Ratih Dewi
AU - Tanjung, Mulyadi
N1 - Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Three chromanone acids were isolated from the stem bark of Calophyllum peekelii Lauterb. Among them are two new chromanone acids, calopeekelioic acids A (1) and B (2), along with calolongic acid (3), Their structures were established by analyzing a combination of HRESIMS, 1 D, and 2 D NMR spectra. Chromanone acids 1-3 were evaluated for their antiplasmodial activity against Plasmodium falciparum strain 3D7. Compounds 1-2 showed high activity with an IC50 value of 1.70 and 1.01 µg/mL, respectively.
AB - Three chromanone acids were isolated from the stem bark of Calophyllum peekelii Lauterb. Among them are two new chromanone acids, calopeekelioic acids A (1) and B (2), along with calolongic acid (3), Their structures were established by analyzing a combination of HRESIMS, 1 D, and 2 D NMR spectra. Chromanone acids 1-3 were evaluated for their antiplasmodial activity against Plasmodium falciparum strain 3D7. Compounds 1-2 showed high activity with an IC50 value of 1.70 and 1.01 µg/mL, respectively.
KW - Calopeekelioic acids A-B
KW - Calophyllum peekelii
KW - antiplasmodial
KW - chromanone acid
UR - http://www.scopus.com/inward/record.url?scp=85128782827&partnerID=8YFLogxK
U2 - 10.1080/14786419.2022.2062754
DO - 10.1080/14786419.2022.2062754
M3 - Article
AN - SCOPUS:85128782827
SN - 1478-6419
JO - Natural Product Research
JF - Natural Product Research
ER -