Two Flavonoids from Stem Bark of Casimiroa edulis and Their Antidiabetic and Antioxidant Activities

K. N.W. Tun; N. S. Aminah; A. N. Kristanti; R. Ramadhan; Y. Takaya

doi:10.1088/1755-1315/217/1/012006

Two Flavonoids from Stem Bark of Casimiroa edulis and Their Antidiabetic and Antioxidant Activities

K. N.W. Tun, N. S. Aminah, A. N. Kristanti, R. Ramadhan, Y. Takaya

Research output: Contribution to journal › Conference article › peer-review

2 Citations (Scopus)

Abstract

Casimiroa edulis Llave et Lex (Rutacae), popularly known as white sapote. The main aim of this study is to isolate and investigate the bioassay of the stem bark of Casimiroa edulis. Two flavonoids were isolated from the methanolic fraction of the stem bark of Casimiroa edulis. The isolated compounds can be identified as 6,7-dimethoxyflavone (1) and 5,6,2′-trimethoxyflavone (2) by using advance spectroscopic methods, including FT-IR, UV, 1D NMR, 2D NMR. Compounds 1 and 2 were evaluated for their antidiabetic and antioxidant activities. The result revealed that the two compounds did not have antidiabetic activity and antioxidant activity. This is the first phytochemical study of 6,7-dimethoxyflavone from the genus Casimiroa.

Original language	English
Article number	012006
Journal	IOP Conference Series: Earth and Environmental Science
Volume	217
Issue number	1
DOIs	https://doi.org/10.1088/1755-1315/217/1/012006
Publication status	Published - 9 Jan 2019
Event	2nd International Conference on Collaboration Seminar of Chemistry and Industry, CoSCI 2018, in conjunction with 23rd Indonesian Society for Biochemistry and Molecular Biology, ISBMB 2018 - Surabaya, Indonesia Duration: 11 Oct 2018 → 12 Oct 2018

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title = "Two Flavonoids from Stem Bark of Casimiroa edulis and Their Antidiabetic and Antioxidant Activities",

abstract = "Casimiroa edulis Llave et Lex (Rutacae), popularly known as white sapote. The main aim of this study is to isolate and investigate the bioassay of the stem bark of Casimiroa edulis. Two flavonoids were isolated from the methanolic fraction of the stem bark of Casimiroa edulis. The isolated compounds can be identified as 6,7-dimethoxyflavone (1) and 5,6,2′-trimethoxyflavone (2) by using advance spectroscopic methods, including FT-IR, UV, 1D NMR, 2D NMR. Compounds 1 and 2 were evaluated for their antidiabetic and antioxidant activities. The result revealed that the two compounds did not have antidiabetic activity and antioxidant activity. This is the first phytochemical study of 6,7-dimethoxyflavone from the genus Casimiroa.",

author = "Tun, {K. N.W.} and Aminah, {N. S.} and Kristanti, {A. N.} and R. Ramadhan and Y. Takaya",

note = "Publisher Copyright: {\textcopyright} 2019 Published under licence by IOP Publishing Ltd.; 2nd International Conference on Collaboration Seminar of Chemistry and Industry, CoSCI 2018, in conjunction with 23rd Indonesian Society for Biochemistry and Molecular Biology, ISBMB 2018 ; Conference date: 11-10-2018 Through 12-10-2018",

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doi = "10.1088/1755-1315/217/1/012006",

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T1 - Two Flavonoids from Stem Bark of Casimiroa edulis and Their Antidiabetic and Antioxidant Activities

AU - Tun, K. N.W.

AU - Aminah, N. S.

AU - Kristanti, A. N.

AU - Ramadhan, R.

AU - Takaya, Y.

PY - 2019/1/9

Y1 - 2019/1/9

N2 - Casimiroa edulis Llave et Lex (Rutacae), popularly known as white sapote. The main aim of this study is to isolate and investigate the bioassay of the stem bark of Casimiroa edulis. Two flavonoids were isolated from the methanolic fraction of the stem bark of Casimiroa edulis. The isolated compounds can be identified as 6,7-dimethoxyflavone (1) and 5,6,2′-trimethoxyflavone (2) by using advance spectroscopic methods, including FT-IR, UV, 1D NMR, 2D NMR. Compounds 1 and 2 were evaluated for their antidiabetic and antioxidant activities. The result revealed that the two compounds did not have antidiabetic activity and antioxidant activity. This is the first phytochemical study of 6,7-dimethoxyflavone from the genus Casimiroa.

AB - Casimiroa edulis Llave et Lex (Rutacae), popularly known as white sapote. The main aim of this study is to isolate and investigate the bioassay of the stem bark of Casimiroa edulis. Two flavonoids were isolated from the methanolic fraction of the stem bark of Casimiroa edulis. The isolated compounds can be identified as 6,7-dimethoxyflavone (1) and 5,6,2′-trimethoxyflavone (2) by using advance spectroscopic methods, including FT-IR, UV, 1D NMR, 2D NMR. Compounds 1 and 2 were evaluated for their antidiabetic and antioxidant activities. The result revealed that the two compounds did not have antidiabetic activity and antioxidant activity. This is the first phytochemical study of 6,7-dimethoxyflavone from the genus Casimiroa.

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DO - 10.1088/1755-1315/217/1/012006

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JO - IOP Conference Series: Earth and Environmental Science

JF - IOP Conference Series: Earth and Environmental Science

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T2 - 2nd International Conference on Collaboration Seminar of Chemistry and Industry, CoSCI 2018, in conjunction with 23rd Indonesian Society for Biochemistry and Molecular Biology, ISBMB 2018

Y2 - 11 October 2018 through 12 October 2018

ER -

Two Flavonoids from Stem Bark of Casimiroa edulis and Their Antidiabetic and Antioxidant Activities

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