Tooth extraction left injured tissues on the socket, which stimulated wound healing response to the damaged area. Fibroblasts are essential cells in wound healing due to their role in synthesizing collagen. With curcumin as its active ingredient, Turmeric has some beneficial properties, such as antioxidants, antimicrobials and antifungals. Zinc oxide works as an anti-inflammatory and antibacterial treatment for wounds. The combination of turmeric extract and zinc oxide is expected to increase fibroblasts and collagen in wound healing on days 3 and 7 and accelerate the process. This study aims to observe the potential of turmeric extract and zinc oxide combination in promoting fibroblasts proliferation and collagen formation in the wound healing process of post tooth extraction socket. Twenty Wistar rats were divided into control (C3, C7) and treatment groups (T3, T4). The mandibular left incisor of Wistar rats was extracted, and turmeric-zinc oxide combination gel was injected into the socket for the treatment groups, while the control groups were left untreated. Half of the mandibular tissue was dissected, and those samples were stained with Haematoxylin-Eosin (HE) and Masson’s Trichrome (MT) staining. The number of fibroblasts and collagens were observed under the light microscope and calculated with a 400x magnification at 20 fields of view of the apical third. The data were analyzed using Anova and Turkey HSD tests. Tests showed a significant increase in the number of fibroblast cells and collagen formation between the treatment groups and the control groups. The combination of turmeric extract and zinc oxide can increase fibroblasts’ proliferation and collagen formation during the wound healing process in the post-extraction socket.
|Number of pages||6|
|Journal||Biochemical and Cellular Archives|
|Publication status||Published - Oct 2020|
- zinc oxide