TY - JOUR
T1 - Tropical Medicinal Plant Extracts from Indonesia as Antifungal Agents against Candida Albicans
AU - Geraldi, Almando
AU - Wardana, Andika Pramudya
AU - Aminah, Nanik Siti
AU - Kristanti, Alfinda Novi
AU - Sadila, Aliffa Yusti
AU - Wijaya, Nabilla Hapsari
AU - Wijaya, Mellya Rimadha Andra
AU - Diningrum, Noviana Indah Dwi
AU - Hajar, Versa Rachmania
AU - Manuhara, Yosephine Sri Wulan
N1 - Publisher Copyright:
© 2022 The Author(s).
PY - 2022/9
Y1 - 2022/9
N2 - Background: Candida albicans is responsible for a wide range of medical ailments, from harmless cutaneous to life-threatening bloodstream infections. Growing cases of antifungal-drug resistance strains of C. albicans become a rationale to explore and develop novel anti-candida agents. In this paper, we assessed the anti-candida activity of the methanolic extracts of various tropical medicinal plants from Myrtaceae, Poaceae, and Zingiberaceae, commonly used in Indonesia to treat fungal infections. Methods: Candida albicans strain ATCC 10231 was used as a subject to assess the anti-Candida activities of plant methanolic extracts through disc diffusion assay. Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) were observed. Results: All plant extracts in this study showed antifungal activities against C. albicans. Among them, Cymbopogon citratus, Curcuma xanthorrhiza, Curcuma aeruginosa, and Zingiber officinale var. rubrum showed the lowest MIC and MFC value of 3.8 mg/mL. Conclusions: The growth inhibition of C. albicans on disc diffusion assay was demonstrated by Z. officinale var. rubrum and C. longa, which were comparable to antifungal nystatin. Further investigation of the chemical constituents of the extracts and the cytotoxicity test is needed to further develop plant-derived anti-candida agents.
AB - Background: Candida albicans is responsible for a wide range of medical ailments, from harmless cutaneous to life-threatening bloodstream infections. Growing cases of antifungal-drug resistance strains of C. albicans become a rationale to explore and develop novel anti-candida agents. In this paper, we assessed the anti-candida activity of the methanolic extracts of various tropical medicinal plants from Myrtaceae, Poaceae, and Zingiberaceae, commonly used in Indonesia to treat fungal infections. Methods: Candida albicans strain ATCC 10231 was used as a subject to assess the anti-Candida activities of plant methanolic extracts through disc diffusion assay. Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) were observed. Results: All plant extracts in this study showed antifungal activities against C. albicans. Among them, Cymbopogon citratus, Curcuma xanthorrhiza, Curcuma aeruginosa, and Zingiber officinale var. rubrum showed the lowest MIC and MFC value of 3.8 mg/mL. Conclusions: The growth inhibition of C. albicans on disc diffusion assay was demonstrated by Z. officinale var. rubrum and C. longa, which were comparable to antifungal nystatin. Further investigation of the chemical constituents of the extracts and the cytotoxicity test is needed to further develop plant-derived anti-candida agents.
KW - Candida albicans
KW - Health care
KW - methanolic extract
KW - minimum fungicidal concentration
KW - minimum inhibitory concentration
KW - tropical medicinal plants
UR - http://www.scopus.com/inward/record.url?scp=85139769226&partnerID=8YFLogxK
U2 - 10.31083/j.fbl2709274
DO - 10.31083/j.fbl2709274
M3 - Article
C2 - 36224024
AN - SCOPUS:85139769226
SN - 2768-6701
VL - 27
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
IS - 9
M1 - 274
ER -