TY - JOUR
T1 - Transcatheter Closure of Perimembranous Ventricular Septal Defect Using the Lifetech Konar-Multi Functional Occluder
T2 - Early to Midterm Results of the Indonesian Multicenter Study
AU - Kuswiyanto, Rahmat Budi
AU - Gunawijaya, Eka
AU - Djer, Mulyadi M.
AU - Noormanto,
AU - Rahman, Mahrus A.
AU - Murni, Indah K.
AU - Sukardi, Rubiana
AU - Utamayasa, Alit
AU - Ardiansyah, Rizky
AU - Nova, Ria
AU - Liliyanti, Sri
AU - Rahayuningsih, Sri E.
AU - Anggriawan, Shirley L.
AU - Rahayuningsih, Tri Yanti
AU - Koentartiwi, Dyahris
AU - Soewarniaty, Renny
AU - Yantie, Venny Kartika
AU - Nugroho, Sasmito
AU - Hidayat, Taufiq
AU - Ontoseno, Teddy
AU - Tobing, Tina C.
AU - Ali, Muhamad
AU - Bashari, Muhammad Hasan
AU - Yosy, Denny S.
AU - Arafuri, Nadya
AU - Hilmanto, Dany
AU - Yanuarso, Piprim B.
AU - Advani, Najib
AU - Sastroasmoro, Sudigdo
AU - Putra, Sukman Tulus
N1 - Funding Information:
The investigators thank to Nagesh Rao Konnetti for pioneering the idea to develop the KONAR-Multi Functional Occluder, and to Worakan Promphan for precious advice during the study period.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022
Y1 - 2022
N2 - Background: The alternative device to close perimembranous ventricular septal defect (pmVSD) has been searched for better result, less complications and applicable for infants. However, the ideal device is still unavailable. We aimed to evaluate the effectiveness and outcome of transcatheter pmVSD closure using the KONAR-multi functional occluder (MFO). Methods: Clinical, procedural, follow-up data of pmVSD patients with symptom of heart failure or evidence of significant left to right shunt, growth failure, recurrent respiratory tract infection, and history of endocarditis who underwent transcatheter closure using the MFO were prospectively evaluated. Results: Between January 2016 and December 2017, there were complete records of 132 pmVSD children closed using MFO from eleven centers in Indonesia. The median of age was 4.5 (0.3-17.4) years; weight 14.8 (3.5-57) kg, defect size at the smallest part 3.4 (1.0-8.1) mm, flow ratio 1.6 (1.3-4.9), mean pulmonary artery pressure 18 (7-79) mmHg, fluoroscopy time 18 (3.8-91) and procedural time 75 (26-290) minutes. A retrograde approach was done in 41 (31%) patients. Procedures succeeded in first attempt in 126 (95.4%), failed in three and migration in three patients. Six of eight infants with congestive heart failure were closed successfully. Of 126 patients with successful VSD closure, 12 months follow-up were completed in all patients. The rate of complete occlusion at 1 month, 3 months, 6 months and 12 months after intervention were 95.2%, 97.6%, 99.2%, and 99.2%, respectively. New-onset aortic regurgitation and moderate tricuspid regurgitation developed only in five and three patients. Neither complete atrioventricular block, nor other complications occurred. Conclusion: Transcatheter closure of pmVSD using the MFO is safe, effective, and feasible in infants and children.
AB - Background: The alternative device to close perimembranous ventricular septal defect (pmVSD) has been searched for better result, less complications and applicable for infants. However, the ideal device is still unavailable. We aimed to evaluate the effectiveness and outcome of transcatheter pmVSD closure using the KONAR-multi functional occluder (MFO). Methods: Clinical, procedural, follow-up data of pmVSD patients with symptom of heart failure or evidence of significant left to right shunt, growth failure, recurrent respiratory tract infection, and history of endocarditis who underwent transcatheter closure using the MFO were prospectively evaluated. Results: Between January 2016 and December 2017, there were complete records of 132 pmVSD children closed using MFO from eleven centers in Indonesia. The median of age was 4.5 (0.3-17.4) years; weight 14.8 (3.5-57) kg, defect size at the smallest part 3.4 (1.0-8.1) mm, flow ratio 1.6 (1.3-4.9), mean pulmonary artery pressure 18 (7-79) mmHg, fluoroscopy time 18 (3.8-91) and procedural time 75 (26-290) minutes. A retrograde approach was done in 41 (31%) patients. Procedures succeeded in first attempt in 126 (95.4%), failed in three and migration in three patients. Six of eight infants with congestive heart failure were closed successfully. Of 126 patients with successful VSD closure, 12 months follow-up were completed in all patients. The rate of complete occlusion at 1 month, 3 months, 6 months and 12 months after intervention were 95.2%, 97.6%, 99.2%, and 99.2%, respectively. New-onset aortic regurgitation and moderate tricuspid regurgitation developed only in five and three patients. Neither complete atrioventricular block, nor other complications occurred. Conclusion: Transcatheter closure of pmVSD using the MFO is safe, effective, and feasible in infants and children.
KW - KONAR-multi functional occluder
KW - Perimembranous ventricular septal defect
KW - transcatheter closure
UR - http://www.scopus.com/inward/record.url?scp=85126654142&partnerID=8YFLogxK
U2 - 10.5334/GH.1106
DO - 10.5334/GH.1106
M3 - Article
AN - SCOPUS:85126654142
SN - 2211-8160
VL - 17
JO - Global Heart
JF - Global Heart
IS - 1
M1 - 15
ER -