TY - JOUR
T1 - Tracking lethal threat
T2 - in-depth review of rabies
AU - Khairullah, Aswin Rafif
AU - Kurniawan, Shendy Canadya
AU - Hasib, Abdullah
AU - Silaen, Otto Sahat Martua
AU - Widodo, Agus
AU - Effendi, Mustofa Helmi
AU - Ramandinianto, Sancaka Chasyer
AU - Moses, Ikechukwu Benjamin
AU - Riwu, Katty Hendriana Priscilia
AU - Yanestria, Sheila Marty
N1 - Publisher Copyright:
© 2023, Faculty of Veterinary Medicine, University of Tripoli. All rights reserved.
PY - 2023
Y1 - 2023
N2 - An infectious disease known as rabies (family Rhabdoviridae, genus Lyssavirus) causes severe damage to mammals’ central nervous systems (CNS). This illness has been around for a very long time. The majority of human cases of rabies take place in underdeveloped regions of Africa and Asia. Following viral transmission, the Rhabdovirus enters the peripheral nervous system and proceeds to the CNS, where it targets the encephalon and produces encephalomyelitis. Postbite prophylaxis requires laboratory confirmation of rabies in both people and animals. All warm-blooded animals can transmit the Lyssavirus infection, while the virus can also develop in the cells of cold-blooded animals. In the 21st century, more than 3 billion people are in danger of contracting the rabies virus in more than 100 different nations, resulting in an annual death toll of 50,000–59,000. There are three important elements in handling rabies disease in post exposure prophylaxis (PEP), namely wound care, administration of anti-rabies serum, and anti-rabies vaccine. Social costs include death, lost productivity as a result of early death, illness as a result of vaccination side effects, and the psychological toll that exposure to these deadly diseases has on people. Humans are most frequently exposed to canine rabies, especially youngsters and the poor, and there are few resources available to treat or prevent exposure, making prevention of human rabies challenging.
AB - An infectious disease known as rabies (family Rhabdoviridae, genus Lyssavirus) causes severe damage to mammals’ central nervous systems (CNS). This illness has been around for a very long time. The majority of human cases of rabies take place in underdeveloped regions of Africa and Asia. Following viral transmission, the Rhabdovirus enters the peripheral nervous system and proceeds to the CNS, where it targets the encephalon and produces encephalomyelitis. Postbite prophylaxis requires laboratory confirmation of rabies in both people and animals. All warm-blooded animals can transmit the Lyssavirus infection, while the virus can also develop in the cells of cold-blooded animals. In the 21st century, more than 3 billion people are in danger of contracting the rabies virus in more than 100 different nations, resulting in an annual death toll of 50,000–59,000. There are three important elements in handling rabies disease in post exposure prophylaxis (PEP), namely wound care, administration of anti-rabies serum, and anti-rabies vaccine. Social costs include death, lost productivity as a result of early death, illness as a result of vaccination side effects, and the psychological toll that exposure to these deadly diseases has on people. Humans are most frequently exposed to canine rabies, especially youngsters and the poor, and there are few resources available to treat or prevent exposure, making prevention of human rabies challenging.
KW - Bite
KW - Infectious disease
KW - Public health
KW - Rabies
KW - Virus
UR - http://www.scopus.com/inward/record.url?scp=85179997944&partnerID=8YFLogxK
U2 - 10.5455/OVJ.2023.V13.I11.1
DO - 10.5455/OVJ.2023.V13.I11.1
M3 - Review article
C2 - 38107233
AN - SCOPUS:85179997944
SN - 2226-4485
VL - 13
SP - 1385
EP - 1399
JO - Open Veterinary Journal
JF - Open Veterinary Journal
IS - 11
ER -