Oral squamous cell carcinoma (OSCC) is a cancerous lesion found explicitly in the oral cavity with five years survival rate of less than 60%. No significant improvement found in overall survival rate despite the technological advancement for the last 30 years, and several reported cases showed treatment resistance, specifically to cisplatin chemotherapy. It is necessary to identify reliable biomarkers to classify the progression stage and to decide the adequate and personalized treatment plans of OSCC. The TP53 gene is the most commonly mutated in OSCC, and its existence frequently compromise wild-type p53 protein function as a tumor suppressor. Mutant p53 is known to have a loss of function (LOF) and gain of function (GOF) characteristic, which both play a pivotal role in the progression of OSCC, though the detail is less described. This review will discuss the TP53 gene, the normal function of p53 protein, the mutation in TP53 and its effect in mutant p53, and the role of mutant p53 in OSCC progression through molecular perspective.

Original languageEnglish
Pages (from-to)2857-2863
Number of pages7
JournalBiochemical and Cellular Archives
Publication statusPublished - 2020


  • Gain of function mutation
  • Loss of function mutation
  • Oral squamous cell carcinoma
  • TP53
  • p53


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