TY - JOUR
T1 - TP53 mutation
T2 - Its role in oral squamous cell carcinoma progression
AU - Puteri, Astari
AU - Prabowo, Gwenny Ichsan
AU - Handajani, Retno
N1 - Publisher Copyright:
© 2020 Connect Journal.
PY - 2020
Y1 - 2020
N2 - Oral squamous cell carcinoma (OSCC) is a cancerous lesion found explicitly in the oral cavity with five years survival rate of less than 60%. No significant improvement found in overall survival rate despite the technological advancement for the last 30 years, and several reported cases showed treatment resistance, specifically to cisplatin chemotherapy. It is necessary to identify reliable biomarkers to classify the progression stage and to decide the adequate and personalized treatment plans of OSCC. The TP53 gene is the most commonly mutated in OSCC, and its existence frequently compromise wild-type p53 protein function as a tumor suppressor. Mutant p53 is known to have a loss of function (LOF) and gain of function (GOF) characteristic, which both play a pivotal role in the progression of OSCC, though the detail is less described. This review will discuss the TP53 gene, the normal function of p53 protein, the mutation in TP53 and its effect in mutant p53, and the role of mutant p53 in OSCC progression through molecular perspective.
AB - Oral squamous cell carcinoma (OSCC) is a cancerous lesion found explicitly in the oral cavity with five years survival rate of less than 60%. No significant improvement found in overall survival rate despite the technological advancement for the last 30 years, and several reported cases showed treatment resistance, specifically to cisplatin chemotherapy. It is necessary to identify reliable biomarkers to classify the progression stage and to decide the adequate and personalized treatment plans of OSCC. The TP53 gene is the most commonly mutated in OSCC, and its existence frequently compromise wild-type p53 protein function as a tumor suppressor. Mutant p53 is known to have a loss of function (LOF) and gain of function (GOF) characteristic, which both play a pivotal role in the progression of OSCC, though the detail is less described. This review will discuss the TP53 gene, the normal function of p53 protein, the mutation in TP53 and its effect in mutant p53, and the role of mutant p53 in OSCC progression through molecular perspective.
KW - Gain of function mutation
KW - Loss of function mutation
KW - Oral squamous cell carcinoma
KW - TP53
KW - p53
UR - http://www.scopus.com/inward/record.url?scp=85090562115&partnerID=8YFLogxK
U2 - 10.35124/bca.2020.20.S1.2857
DO - 10.35124/bca.2020.20.S1.2857
M3 - Article
AN - SCOPUS:85090562115
SN - 0972-5075
VL - 20
SP - 2857
EP - 2863
JO - Biochemical and Cellular Archives
JF - Biochemical and Cellular Archives
ER -