TY - JOUR
T1 - Topical Administration Effect of Sargassum duplicatum and Garcinia mangostana Extracts Combination on Open Wound Healing Process in Diabetic Mice
AU - Winarni, Dwi
AU - Husna, Fitria Nikmatul
AU - Syadzha, Muhammad Farraz
AU - Susilo, Raden Joko Kuncoroningrat
AU - Hayaza, Suhailah
AU - Ansori, Arif Nur Muhammad
AU - Alamsjah, Mochammad Amin
AU - Amin, Muhamad Nur Ghoyatul
AU - Wulandari, Pugar Arga Christina
AU - Pudjiastuti, Pratiwi
AU - Awang, Khalijah
N1 - Publisher Copyright:
© 2022 Dwi Winarni et al.
PY - 2022
Y1 - 2022
N2 - This research aimed to determine the topical administration effect of the combination of Sargassum duplicatum and Garcinia mangostana extracts to ameliorate diabetic open wound healing. The study used 24 adult males of Mus musculus (BALB/c strain, 3-4 months, 30-40 g). They were divided into normal control groups (KN) and diabetic groups. The diabetic group was streptozotocin-induced and divided further into three treatment groups: the diabetic control group (KD), the S. duplicatum treatment group (PA), and the combination of S. duplicatum and G. mangostana treatment group (PAM). The dose of treatment was 50 mg/kg of body weight. Each group was divided into three treatment durations, which were 3 days, 7 days, and 14 days. The wound healing process was determined by wound width, the number of neutrophils, macrophages, fibroblasts, fibrocytes, and collagen density. Histological observation showed that the topical administration of combination extracts increased the re-epithelialization of the wounded area, fibroblasts, fibrocytes, and collagen synthesis. The topical administration of combination extracts also decreased the number of neutrophils and macrophages. This study concluded that the topical administration of the combination of S. duplicatum and G. mangostana extracts improved the open wound healing process in diabetic mice.
AB - This research aimed to determine the topical administration effect of the combination of Sargassum duplicatum and Garcinia mangostana extracts to ameliorate diabetic open wound healing. The study used 24 adult males of Mus musculus (BALB/c strain, 3-4 months, 30-40 g). They were divided into normal control groups (KN) and diabetic groups. The diabetic group was streptozotocin-induced and divided further into three treatment groups: the diabetic control group (KD), the S. duplicatum treatment group (PA), and the combination of S. duplicatum and G. mangostana treatment group (PAM). The dose of treatment was 50 mg/kg of body weight. Each group was divided into three treatment durations, which were 3 days, 7 days, and 14 days. The wound healing process was determined by wound width, the number of neutrophils, macrophages, fibroblasts, fibrocytes, and collagen density. Histological observation showed that the topical administration of combination extracts increased the re-epithelialization of the wounded area, fibroblasts, fibrocytes, and collagen synthesis. The topical administration of combination extracts also decreased the number of neutrophils and macrophages. This study concluded that the topical administration of the combination of S. duplicatum and G. mangostana extracts improved the open wound healing process in diabetic mice.
UR - http://www.scopus.com/inward/record.url?scp=85125843253&partnerID=8YFLogxK
U2 - 10.1155/2022/9700794
DO - 10.1155/2022/9700794
M3 - Article
AN - SCOPUS:85125843253
SN - 2090-908X
VL - 2022
JO - Scientifica
JF - Scientifica
M1 - 9700794
ER -
