TNF-a serum Level between SARS-CoV-2 Infected Pregnant women with normal pregnant women in RSUD Dr. Soetomo Surabaya

Introduction: Pregnant women infected with SARS-CoV-2 experienced increased pro-inflammatory cytokines, including TNF-a, resulting in a cytokine storm condition. This study compares TNF-a levels between pregnant women infected and not infected with Covid-19 in the 3rd trimester. Methods: This observational research was conducted with cross sectional design. Our study included pregnant women who came to delivery room/inpatient at RSUD Dr. Soetomo Surabaya before or during the labor period between May and June in 2021. The inclusion criteria were 3rd trimester gestational age or > 28 weeks with SARS-RT-PCR nasopharyngeal swab result. The exclusion criteria were all significant pregnancy complications. The pregnant woman coming to the delivery room will be screened for COVID-19, and blood samples will be examined using the flow cytometry method for the cytokine Th1: TNF-α. Results: There were no significant differences in TNF-a levels in pregnant women who were infected and not infected with COVID-19 (median 3.42 (7.24) pg/ml vs. 2.70 (3.06) pg/ml. p=0.138). There were also no significant differences in TNF-a levels in pregnant women with symptomatic vs. asymptomatic COVID infection (3.21(3.97) vs. 2.41(2.71) pg/ml; p=0.314). Conclusion: This study revealed no significant difference in TNF-a serum level between SARS-CoV-2 infected pregnant women with normal pregnant women.