Thymoquinone potency in denture plaque hydrolysis in vitro

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The prolonged accumulated plaque, may lead to microorganism multiplication, thus causing pathological changes in oral cavity. Dental plaque consists of 20%-30% intercelullar matrices and 70% microorganisms. Thymoquinone denotes bio-active agent extracted from plants that has antibacterial and antifungal activity. This study aimed to determine the effective concentration of thymoquinone to detached plaque from acrylic plate. This was an analytical laboratory study involving denture users as sample. The accumulated denture plaque was replicated in BHIB solution. Acrylic plates were immersed in BHIB, and divided into groups for hydrolysis assessment; control group, then were macerated in distilled water; as for treatment group, the plates were macerated in thymoquinone in varying concentration for a range of time periods. Optical density of hydrolysis result analysis was done at a wavelength of 600nm. Result. The lowest hydrolysis rate recorded was control group, with mean of 31.32%. Thymoquinone at 50% concentration, with 10 minutes maceration periods showed the highest hydrolysis rate (74.42%). The effective concentration of thymoquinone for denture plaque hydrolysis is 50%, soaked for 10 minutes.

Original languageEnglish
Pages (from-to)953-958
Number of pages6
JournalJournal of International Dental and Medical Research
Issue number3
Publication statusPublished - 2019


  • Denture plaque
  • Hydrolysis
  • Thymoquinone


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