Three novel quinolinone alkaloids from the leaves of Melicope denhamii

Ratih Dewi Saputri; Rurini Retnowati; Unang Supratman; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung

doi:10.1080/14786419.2021.1960524

Three novel quinolinone alkaloids from the leaves of Melicope denhamii

Ratih Dewi Saputri, Rurini Retnowati, Unang Supratman, Tjitjik Srie Tjahjandarie, Mulyadi Tanjung

Faculty of Science and Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Three previously unreported quinolinone alkaloids: melicodenines J-L (1-3) and six known compounds (4-9), were isolated from the leaves of Melicope denhamii (Seem) T.G. Hartley. The structures of three quinolinone alkaloids were identified based on HRESIMS and NMR spectra. Compounds 1-9 were assayed in three cancer cells (MCF-7, HeLa, and P-388). Compounds 1 and 5 showed high cytotoxic activity against HeLa cells with IC₅₀ values of 1.8 and 0.8 µM, respectively.

Original language	English
Pages (from-to)	197-203
Number of pages	7
Journal	Natural Product Research
Volume	37
Issue number	2
DOIs	https://doi.org/10.1080/14786419.2021.1960524
Publication status	Published - 2023

Keywords

Melicope denhamii
cytotoxic
melicodenines J-L
quinolinone adduct

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10.1080/14786419.2021.1960524

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title = "Three novel quinolinone alkaloids from the leaves of Melicope denhamii",

abstract = "Three previously unreported quinolinone alkaloids: melicodenines J-L (1-3) and six known compounds (4-9), were isolated from the leaves of Melicope denhamii (Seem) T.G. Hartley. The structures of three quinolinone alkaloids were identified based on HRESIMS and NMR spectra. Compounds 1-9 were assayed in three cancer cells (MCF-7, HeLa, and P-388). Compounds 1 and 5 showed high cytotoxic activity against HeLa cells with IC50 values of 1.8 and 0.8 µM, respectively.",

keywords = "Melicope denhamii, cytotoxic, melicodenines J-L, quinolinone adduct",

author = "Saputri, {Ratih Dewi} and Rurini Retnowati and Unang Supratman and Tjahjandarie, {Tjitjik Srie} and Mulyadi Tanjung",

note = "Funding Information: This research financially supported by Universitas Airlangga, Surabaya, Indonesia (Hibah Mandat 2019 by Tjitjik Srie Tjahjandarie). Publisher Copyright: {\textcopyright} 2021 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2023",

doi = "10.1080/14786419.2021.1960524",

language = "English",

volume = "37",

pages = "197--203",

journal = "Natural Product Research",

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T1 - Three novel quinolinone alkaloids from the leaves of Melicope denhamii

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AU - Retnowati, Rurini

AU - Supratman, Unang

AU - Tjahjandarie, Tjitjik Srie

AU - Tanjung, Mulyadi

N1 - Funding Information: This research financially supported by Universitas Airlangga, Surabaya, Indonesia (Hibah Mandat 2019 by Tjitjik Srie Tjahjandarie). Publisher Copyright: © 2021 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2023

Y1 - 2023

N2 - Three previously unreported quinolinone alkaloids: melicodenines J-L (1-3) and six known compounds (4-9), were isolated from the leaves of Melicope denhamii (Seem) T.G. Hartley. The structures of three quinolinone alkaloids were identified based on HRESIMS and NMR spectra. Compounds 1-9 were assayed in three cancer cells (MCF-7, HeLa, and P-388). Compounds 1 and 5 showed high cytotoxic activity against HeLa cells with IC50 values of 1.8 and 0.8 µM, respectively.

AB - Three previously unreported quinolinone alkaloids: melicodenines J-L (1-3) and six known compounds (4-9), were isolated from the leaves of Melicope denhamii (Seem) T.G. Hartley. The structures of three quinolinone alkaloids were identified based on HRESIMS and NMR spectra. Compounds 1-9 were assayed in three cancer cells (MCF-7, HeLa, and P-388). Compounds 1 and 5 showed high cytotoxic activity against HeLa cells with IC50 values of 1.8 and 0.8 µM, respectively.

KW - Melicope denhamii

KW - cytotoxic

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KW - quinolinone adduct

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EP - 203

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JF - Natural Product Research

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ER -

Three novel quinolinone alkaloids from the leaves of Melicope denhamii

Abstract

Keywords

UN SDGs

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