Three novel quinolinone alkaloids from the leaves of Melicope denhamii

Ratih Dewi Saputri, Rurini Retnowati, Unang Supratman, Tjitjik Srie Tjahjandarie, Mulyadi Tanjung

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Three previously unreported quinolinone alkaloids: melicodenines J-L (1-3) and six known compounds (4-9), were isolated from the leaves of Melicope denhamii (Seem) T.G. Hartley. The structures of three quinolinone alkaloids were identified based on HRESIMS and NMR spectra. Compounds 1-9 were assayed in three cancer cells (MCF-7, HeLa, and P-388). Compounds 1 and 5 showed high cytotoxic activity against HeLa cells with IC50 values of 1.8 and 0.8 µM, respectively.

Original languageEnglish
Pages (from-to)197-203
Number of pages7
JournalNatural Product Research
Volume37
Issue number2
DOIs
Publication statusPublished - 2023

Keywords

  • Melicope denhamii
  • cytotoxic
  • melicodenines J-L
  • quinolinone adduct

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