Three novel dihydrochalcones from Flemingia lineata (L.) W.T. Aiton and their antiplasmodial activity

Ratih Dewi Saputri, First Ambar Wati, Amalia Putri Purnamasari, Hilkatul Ilmi, Tjitjik Srie Tjahjandarie, Shola Mardhiyyah, Mulyadi Tanjung

Research output: Contribution to journalArticlepeer-review

Abstract

Three novel dihydrochalcones, flemilineatins C–E (1–3), and two known flavanones (4–5) were isolated from Flemingia lineata (L.) W.T. Aiton leaves. Dihydrochalcones 1–3 structures were established using NMR spectrum and high-resolution ESIMS data. Compounds 1–5 were assayed to Plasmodium falciparum lactate dehydrogenase (PfLDH) for their antiplasmodial activity. Compounds 2 and 5 exhibited high activity with an IC50 value of 0.74 and 0.79 µg/mL, respectively.

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusAccepted/In press - 2024

Keywords

  • antiplasmodial
  • dihydrochalcone
  • Fabaceae
  • flemilineatins C–E
  • Flemingia lineata

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