Three novel dihydrochalcones from Flemingia lineata (L.) W.T. Aiton and their antiplasmodial activity

Ratih Dewi Saputri; First Ambar Wati; Amalia Putri Purnamasari; Hilkatul Ilmi; Tjitjik Srie Tjahjandarie; Shola Mardhiyyah; Mulyadi Tanjung

doi:10.1080/14786419.2024.2349246

Three novel dihydrochalcones from Flemingia lineata (L.) W.T. Aiton and their antiplasmodial activity

Ratih Dewi Saputri, First Ambar Wati, Amalia Putri Purnamasari, Hilkatul Ilmi, Tjitjik Srie Tjahjandarie, Shola Mardhiyyah, Mulyadi Tanjung

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Three novel dihydrochalcones, flemilineatins C–E (1–3), and two known flavanones (4–5) were isolated from Flemingia lineata (L.) W.T. Aiton leaves. Dihydrochalcones 1–3 structures were established using NMR spectrum and high-resolution ESIMS data. Compounds 1–5 were assayed to Plasmodium falciparum lactate dehydrogenase (PfLDH) for their antiplasmodial activity. Compounds 2 and 5 exhibited high activity with an IC₅₀ value of 0.74 and 0.79 µg/mL, respectively.

Original language	English
Journal	Natural Product Research
DOIs	https://doi.org/10.1080/14786419.2024.2349246
Publication status	Accepted/In press - 2024

Keywords

Fabaceae
Flemingia lineata
antiplasmodial
dihydrochalcone
flemilineatins C–E

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10.1080/14786419.2024.2349246

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title = "Three novel dihydrochalcones from Flemingia lineata (L.) W.T. Aiton and their antiplasmodial activity",

abstract = "Three novel dihydrochalcones, flemilineatins C–E (1–3), and two known flavanones (4–5) were isolated from Flemingia lineata (L.) W.T. Aiton leaves. Dihydrochalcones 1–3 structures were established using NMR spectrum and high-resolution ESIMS data. Compounds 1–5 were assayed to Plasmodium falciparum lactate dehydrogenase (PfLDH) for their antiplasmodial activity. Compounds 2 and 5 exhibited high activity with an IC50 value of 0.74 and 0.79 µg/mL, respectively.",

keywords = "Fabaceae, Flemingia lineata, antiplasmodial, dihydrochalcone, flemilineatins C–E",

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doi = "10.1080/14786419.2024.2349246",

language = "English",

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T1 - Three novel dihydrochalcones from Flemingia lineata (L.) W.T. Aiton and their antiplasmodial activity

AU - Saputri, Ratih Dewi

AU - Wati, First Ambar

AU - Purnamasari, Amalia Putri

AU - Ilmi, Hilkatul

AU - Tjahjandarie, Tjitjik Srie

AU - Mardhiyyah, Shola

AU - Tanjung, Mulyadi

PY - 2024

Y1 - 2024

N2 - Three novel dihydrochalcones, flemilineatins C–E (1–3), and two known flavanones (4–5) were isolated from Flemingia lineata (L.) W.T. Aiton leaves. Dihydrochalcones 1–3 structures were established using NMR spectrum and high-resolution ESIMS data. Compounds 1–5 were assayed to Plasmodium falciparum lactate dehydrogenase (PfLDH) for their antiplasmodial activity. Compounds 2 and 5 exhibited high activity with an IC50 value of 0.74 and 0.79 µg/mL, respectively.

AB - Three novel dihydrochalcones, flemilineatins C–E (1–3), and two known flavanones (4–5) were isolated from Flemingia lineata (L.) W.T. Aiton leaves. Dihydrochalcones 1–3 structures were established using NMR spectrum and high-resolution ESIMS data. Compounds 1–5 were assayed to Plasmodium falciparum lactate dehydrogenase (PfLDH) for their antiplasmodial activity. Compounds 2 and 5 exhibited high activity with an IC50 value of 0.74 and 0.79 µg/mL, respectively.

KW - Fabaceae

KW - Flemingia lineata

KW - antiplasmodial

KW - dihydrochalcone

KW - flemilineatins C–E

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U2 - 10.1080/14786419.2024.2349246

DO - 10.1080/14786419.2024.2349246

M3 - Article

C2 - 38717217

AN - SCOPUS:85192571316

SN - 1478-6419

JO - Natural Product Research

JF - Natural Product Research

ER -

Three novel dihydrochalcones from Flemingia lineata (L.) W.T. Aiton and their antiplasmodial activity

Abstract

Keywords

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