Three new dihydrochalcones from the leaves of Artocarpus sericicarpus Jarrett and their activity against Plasmodium falciparum

Lidya Tumewu; Hilkatul Ilmi; Defi Kartika Sari; Adita Ayu Permanasari; Hanifah Khairun Nisa; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung; Che Puteh Osman; Nor Hadiani Ismail; Aty Widyawaruyanti; Achmad Fuad Hafid

doi:10.1080/14786419.2024.2308726

Three new dihydrochalcones from the leaves of Artocarpus sericicarpus Jarrett and their activity against Plasmodium falciparum

Lidya Tumewu, Hilkatul Ilmi, Defi Kartika Sari, Adita Ayu Permanasari, Hanifah Khairun Nisa, Ratih Dewi Saputri, Tjitjik Srie Tjahjandarie, Mulyadi Tanjung, Che Puteh Osman, Nor Hadiani Ismail, Suciati, Aty Widyawaruyanti, Achmad Fuad Hafid

Research output: Contribution to journal › Article › peer-review

Abstract

Three new dihydrochalcones: artoserichalcone A-C (1-3), were isolated from the leaves of Artocarpus sericicarpus. The structures of compounds were determined based on NMR spectrum (¹H, ¹³C, and 2D) and HRESIMS spectroscopic analysis. Compounds (1) and (3) showed active antimalarial activity with IC₅₀ values of 16.90 and 13.56 µM, respectively. Meanwhile, compound (2) with an IC₅₀ value of 63.01 µM was categorised as a moderate antimalarial substance. The cytotoxicity against Huh7, HepG2, BHK-21, and Vero cells showed that compounds (1-3) with CC₅₀ values > 20 µg/mL could be considered non-cytotoxic. Compounds (1-3) exhibited antimalarial activity against Plasmodium falciparum and non-toxic as an antimalarial agent.

Original language	English
Journal	Natural Product Research
DOIs	https://doi.org/10.1080/14786419.2024.2308726
Publication status	Accepted/In press - 2024

Keywords

Artocarpus sericicarpus
antimalarial
artoserichalcone A-C
cytotoxicity
dihydrochalcones

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10.1080/14786419.2024.2308726

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Tumewu, L., Ilmi, H., Kartika Sari, D., Permanasari, A. A., Khairun Nisa, H., Saputri, R. D., Tjahjandarie, T. S., Tanjung, M., Osman, C. P., Ismail, N. H., Suciati , Widyawaruyanti, A., & Hafid, A. F. (Accepted/In press). Three new dihydrochalcones from the leaves of Artocarpus sericicarpus Jarrett and their activity against Plasmodium falciparum. Natural Product Research. https://doi.org/10.1080/14786419.2024.2308726

@article{dab37d5067b44c7a9417e699e4e7cc83,

title = "Three new dihydrochalcones from the leaves of Artocarpus sericicarpus Jarrett and their activity against Plasmodium falciparum",

abstract = "Three new dihydrochalcones: artoserichalcone A-C (1-3), were isolated from the leaves of Artocarpus sericicarpus. The structures of compounds were determined based on NMR spectrum (1H, 13C, and 2D) and HRESIMS spectroscopic analysis. Compounds (1) and (3) showed active antimalarial activity with IC50 values of 16.90 and 13.56 µM, respectively. Meanwhile, compound (2) with an IC50 value of 63.01 µM was categorised as a moderate antimalarial substance. The cytotoxicity against Huh7, HepG2, BHK-21, and Vero cells showed that compounds (1-3) with CC50 values > 20 µg/mL could be considered non-cytotoxic. Compounds (1-3) exhibited antimalarial activity against Plasmodium falciparum and non-toxic as an antimalarial agent.",

keywords = "Artocarpus sericicarpus, antimalarial, artoserichalcone A-C, cytotoxicity, dihydrochalcones",

author = "Lidya Tumewu and Hilkatul Ilmi and {Kartika Sari}, Defi and Permanasari, {Adita Ayu} and {Khairun Nisa}, Hanifah and Saputri, {Ratih Dewi} and Tjahjandarie, {Tjitjik Srie} and Mulyadi Tanjung and Osman, {Che Puteh} and Ismail, {Nor Hadiani} and Suciati and Aty Widyawaruyanti and Hafid, {Achmad Fuad}",

note = "Publisher Copyright: {\textcopyright} 2024 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2024",

doi = "10.1080/14786419.2024.2308726",

language = "English",

journal = "Natural Product Research",

issn = "1478-6419",

publisher = "Taylor and Francis Ltd.",

}

Tumewu, L, Ilmi, H, Kartika Sari, D, Permanasari, AA, Khairun Nisa, H, Saputri, RD, Tjahjandarie, TS , Tanjung, M, Osman, CP, Ismail, NH, Suciati, , Widyawaruyanti, A & Hafid, AF 2024, 'Three new dihydrochalcones from the leaves of Artocarpus sericicarpus Jarrett and their activity against Plasmodium falciparum', Natural Product Research. https://doi.org/10.1080/14786419.2024.2308726

TY - JOUR

T1 - Three new dihydrochalcones from the leaves of Artocarpus sericicarpus Jarrett and their activity against Plasmodium falciparum

AU - Tumewu, Lidya

AU - Ilmi, Hilkatul

AU - Kartika Sari, Defi

AU - Permanasari, Adita Ayu

AU - Khairun Nisa, Hanifah

AU - Saputri, Ratih Dewi

AU - Tjahjandarie, Tjitjik Srie

AU - Tanjung, Mulyadi

AU - Osman, Che Puteh

AU - Ismail, Nor Hadiani

AU - Suciati,

AU - Widyawaruyanti, Aty

AU - Hafid, Achmad Fuad

PY - 2024

Y1 - 2024

N2 - Three new dihydrochalcones: artoserichalcone A-C (1-3), were isolated from the leaves of Artocarpus sericicarpus. The structures of compounds were determined based on NMR spectrum (1H, 13C, and 2D) and HRESIMS spectroscopic analysis. Compounds (1) and (3) showed active antimalarial activity with IC50 values of 16.90 and 13.56 µM, respectively. Meanwhile, compound (2) with an IC50 value of 63.01 µM was categorised as a moderate antimalarial substance. The cytotoxicity against Huh7, HepG2, BHK-21, and Vero cells showed that compounds (1-3) with CC50 values > 20 µg/mL could be considered non-cytotoxic. Compounds (1-3) exhibited antimalarial activity against Plasmodium falciparum and non-toxic as an antimalarial agent.

AB - Three new dihydrochalcones: artoserichalcone A-C (1-3), were isolated from the leaves of Artocarpus sericicarpus. The structures of compounds were determined based on NMR spectrum (1H, 13C, and 2D) and HRESIMS spectroscopic analysis. Compounds (1) and (3) showed active antimalarial activity with IC50 values of 16.90 and 13.56 µM, respectively. Meanwhile, compound (2) with an IC50 value of 63.01 µM was categorised as a moderate antimalarial substance. The cytotoxicity against Huh7, HepG2, BHK-21, and Vero cells showed that compounds (1-3) with CC50 values > 20 µg/mL could be considered non-cytotoxic. Compounds (1-3) exhibited antimalarial activity against Plasmodium falciparum and non-toxic as an antimalarial agent.

KW - Artocarpus sericicarpus

KW - antimalarial

KW - artoserichalcone A-C

KW - cytotoxicity

KW - dihydrochalcones

UR - http://www.scopus.com/inward/record.url?scp=85183871546&partnerID=8YFLogxK

U2 - 10.1080/14786419.2024.2308726

DO - 10.1080/14786419.2024.2308726

M3 - Article

AN - SCOPUS:85183871546

SN - 1478-6419

JO - Natural Product Research

JF - Natural Product Research

ER -

Three new dihydrochalcones from the leaves of Artocarpus sericicarpus Jarrett and their activity against Plasmodium falciparum

Abstract

Keywords

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