Therapeutic potential of avian paramyxovirus serotype 1 for cancer therapy

Arif Nur Muhammad Ansori, Amaq Fadholly, Viol Dhea Kharisma, Alexander Patera Nugraha

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Newcastle disease virus (NDV) or avian paramyxovirus serotype-1 (APMV-1) (Paramyxoviridae: Avulavirus) is recognized as one of the highly contagious and lethal virus of poultry industry globally. On the other hand, every year, morbidity and mortality caused by cancer are increasing globally. In 2014, the WHO stated that 103,100 men and 92,200 women died from cancer in Indonesia. WHO predicted that in 2030 there will be a surge in cancer patients in Indonesia up to seven times. However, the most dominant cancers are the lung, liver and colorectum in men and the breast, cervical, and lung cancers in women. In addition, development of cancer therapy with high effectiveness and selectivity towards cancer cells, as well as minimal side effects on normal cells is needed. Furthermore, NDV is a promising oncolytic virus that especially infects and kills human cancer cells. This virus, known as an oncolytic virus, can kill cancer cells without damaging healthy cells. In this review article, we demonstratedthe current update of NDV virotherapy against various human cancers.

Original languageEnglish
Pages (from-to)2827-2832
Number of pages6
JournalBiochemical and Cellular Archives
Volume20
DOIs
Publication statusPublished - 2020

Keywords

  • Cancer therapy
  • Communicable diseases
  • Newcastle disease virus
  • Virotherapy

Fingerprint

Dive into the research topics of 'Therapeutic potential of avian paramyxovirus serotype 1 for cancer therapy'. Together they form a unique fingerprint.

Cite this