TY - JOUR
T1 - Therapeutic effect of okra (Abelmoschus esculentus moench) pods extract on streptozotocin-induced type-2 diabetic mice
AU - Husen, Saikhu A.
AU - Ansori, Arif N.M.
AU - Hayaza, Suhailah
AU - Susilo, Raden J.K.
AU - Zuraidah, Ayu A.
AU - Winarni, Dwi
AU - Punnapayak, Hunsa
AU - Darmanto, Win
N1 - Funding Information:
Authors would like to thank the Head of Institute of Innovation and Research in Universitas Airlangga for the opportunity which was given to conduct this study funded by the Ministry of Research, Technology, and Higher Education of the Republic of Indonesia. Moreover, special thanks to PMDSU Scholarship - Batch III by The Ministry of Research, Technology, and Higher Education of the Republic of Indonesia which was awarded to Arif Nur Muhammad Ansori, Suhailah Hayaza, and Raden Joko Kuncoroningrat Susilo.
Publisher Copyright:
© RJPT All right reserved.
PY - 2019/8
Y1 - 2019/8
N2 - The aims of this study were to determine the effect of various fractions of okra pods extract (VOPE) to the changes of fasting blood glucose, serum insulin, and GLUT4 density on streptozotocin-induced type-2 diabetic mice. This study employed 36 male Balb/c strain mice. The samples were divided into seven groups, KN (normal control), KD (diabetic control), KA (acarbose control), EK (crude extract), NP (non-polar), SP (semi-polar), and EP (polar). VOPE and acarbose were administered orally for 14 days in streptozotocin-induced type-2 diabetic mice. Mice with type-2 diabetes mellitus were induced by the intraperitoneal injection of multiple low-dose streptozotocin (30 mg/kg body weight) daily for five consecutive days. On 15th day, mice were terminated. The data of fasting blood glucose, serum insulin, and GLUT4 density were analyzed and interestingly it showed that the administration of VOPE could ameliorate the fasting blood glucose, serum insulin, and GLUT4 density. Therefore, it can be suggested that VOPE can be regarded as a promising antidiabetic agent in the streptozotocin-induced diabetic mice.
AB - The aims of this study were to determine the effect of various fractions of okra pods extract (VOPE) to the changes of fasting blood glucose, serum insulin, and GLUT4 density on streptozotocin-induced type-2 diabetic mice. This study employed 36 male Balb/c strain mice. The samples were divided into seven groups, KN (normal control), KD (diabetic control), KA (acarbose control), EK (crude extract), NP (non-polar), SP (semi-polar), and EP (polar). VOPE and acarbose were administered orally for 14 days in streptozotocin-induced type-2 diabetic mice. Mice with type-2 diabetes mellitus were induced by the intraperitoneal injection of multiple low-dose streptozotocin (30 mg/kg body weight) daily for five consecutive days. On 15th day, mice were terminated. The data of fasting blood glucose, serum insulin, and GLUT4 density were analyzed and interestingly it showed that the administration of VOPE could ameliorate the fasting blood glucose, serum insulin, and GLUT4 density. Therefore, it can be suggested that VOPE can be regarded as a promising antidiabetic agent in the streptozotocin-induced diabetic mice.
KW - Abelmoschus esculentus Moench
KW - Diabetic Mice
KW - Fasting Blood Glucose
KW - GLUT4 Density
KW - Serum Insulin
UR - http://www.scopus.com/inward/record.url?scp=85071634008&partnerID=8YFLogxK
U2 - 10.5958/0974-360X.2019.00633.4
DO - 10.5958/0974-360X.2019.00633.4
M3 - Article
AN - SCOPUS:85071634008
SN - 0974-3618
VL - 12
SP - 3703
EP - 3708
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
IS - 8
ER -
