The thickness of type i collagen fiber on vaginal wall associated with the degree of anterior pelvic organ prolapse

Eighty Mardiyan Kurniawati, Nurlaella Iswan Nusi, Sjahjenny Mustokoweni, Hari Paraton, Gatut Hardiyanto, Azami Denas Azinar, Tri Hastono Setyo Hadi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Pelvic organ prolapse (POP) is estimated to affect almost 50% of women above the age of 50 years. However, the pathophysiology of prolapse is still unclear. This study aimed to analyze the correlation of the thickness of type I collagen fibers with the degree of anterior POP. The samples were divided into four groups; prolapse grade 0/I, grade II, grade III, and grade IV. The immunohistochemical staining was performed with type 1 collagen antibody to assess the thickness of type 1 collagen fibers using indirect immunoenzyme techniques. There was no difference in the age, parity, and menopause status of patients (P = 0.276; P = 0.984; P = 0.418, respectively) in all groups. Mean thicknesses of fibers of type 1 collagen patients with anterior POP in grade 0/I, II, III and IV were 3,634±0.0656 μm; 3,083±0.0174 μm; 2,585±0.0119 μm and 1,562±0.0922 μm, respectively. There was strong negative correlation between type 1 collagen fibers thickness and the degree of anterior POP (r =-0.969, p <0.0001). There was strong negative correlation between type 1 collagen fiber thickness and the degree of anterior POP.

Original languageEnglish
Pages (from-to)611-615
Number of pages5
JournalSystematic Reviews in Pharmacy
Volume11
Issue number5
DOIs
Publication statusPublished - 2020

Keywords

  • Collagen type i
  • Pelvic organ prolapse
  • The vaginal wall

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