TY - JOUR
T1 - The roles of C-reactive protein-albumin ratio as a novel prognostic biomarker in heart failure patients
T2 - A systematic review
AU - Kurniawan, Roy Bagus
AU - Oktafia, Pratista
AU - Saputra, Pandit Bagus Tri
AU - Purwati, Dinda Dwi
AU - Saputra, Mahendra Eko
AU - Maghfirah, Irma
AU - Faizah, Novia Nurul
AU - Oktaviono, Yudi Her
AU - Alkaff, Firas Farisi
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/5
Y1 - 2024/5
N2 - C-Reactive Protein (CRP)-albumin ratio (CAR) is a novel prognostic biomarker that is predicted to be a more reliable indicator than CRP or albumin alone. Therefore, this systematic review aimed to evaluate the role of CAR in predicting poor outcomes of heart failure (HF) patients. We conducted a literature search across ProQuest, PubMed, ScienceDirect, Web of Science, and Scopus. All related studies assessing CAR and reporting mortality outcomes or other adverse outcomes were assessed. A total of five studies with a total of 1821 patients were included in this review. CAR is significantly associated with all-causes in-hospital mortality and out-hospital mortality in patients with acute and chronic heart failure. CAR is associated with higher hospitalization rates, the number of hospitalizations, severe New York Heart Association (NYHA) classification, and the risk of advanced HF. In conclusion, CAR is significantly associated with poor HF outcomes including all-cause mortality (cardiac and non-cardiac death).
AB - C-Reactive Protein (CRP)-albumin ratio (CAR) is a novel prognostic biomarker that is predicted to be a more reliable indicator than CRP or albumin alone. Therefore, this systematic review aimed to evaluate the role of CAR in predicting poor outcomes of heart failure (HF) patients. We conducted a literature search across ProQuest, PubMed, ScienceDirect, Web of Science, and Scopus. All related studies assessing CAR and reporting mortality outcomes or other adverse outcomes were assessed. A total of five studies with a total of 1821 patients were included in this review. CAR is significantly associated with all-causes in-hospital mortality and out-hospital mortality in patients with acute and chronic heart failure. CAR is associated with higher hospitalization rates, the number of hospitalizations, severe New York Heart Association (NYHA) classification, and the risk of advanced HF. In conclusion, CAR is significantly associated with poor HF outcomes including all-cause mortality (cardiac and non-cardiac death).
KW - Adverse outcome
KW - CRP-albumin ratio
KW - Heart failure
KW - Mortality
KW - Prognostic
UR - http://www.scopus.com/inward/record.url?scp=85186623447&partnerID=8YFLogxK
U2 - 10.1016/j.cpcardiol.2024.102475
DO - 10.1016/j.cpcardiol.2024.102475
M3 - Review article
C2 - 38401823
AN - SCOPUS:85186623447
SN - 0146-2806
VL - 49
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
IS - 5
M1 - 102475
ER -