The role of Wnt signaling on Tooth Extraction Wound Healing: Narrative review

Christian Khoswanto, Ira Kusuma Dewi

Research output: Contribution to journalReview articlepeer-review


Compared to an incisional skin or mucosal wound, a tooth extraction wound results in far more soft tissue loss. A blood clot instantly fills the gap left by the extracted tooth. An embryonic type of bone forms during the healing of extraction wounds, and mature bone only later replaces it. Osteocytes in embryonic bone, also known as coarse fibrillar bone or immature bone, differ from those in adult bone in terms of number, size, and irregular arrangement. This immature bone is more radiolucent than mature bone due to the higher cell density and the smaller volume of calcified intercellular material. The Wnt gene family contains genes that encode secreted signaling proteins that have good promise for promoting bone regeneration. However, we still have a limited understanding the interplay of the molecular elements of the Wnt pathway in signal transduction, from ligand detection on the cell surface to transcription of target genes in the nucleus. We discuss the function of Wnt signaling molecules in this review, in tissue repair following tooth extraction and present recent results about these molecules. Conclusions: Wnt signaling activity helps to hasten bone regeneration while bone healing is slowed down by mutations in LRP5/6 or β-catenin.

Original languageEnglish
Pages (from-to)516-520
Number of pages5
JournalSaudi Dental Journal
Issue number4
Publication statusPublished - Apr 2024


  • Tooth Extraction
  • Wnt Signaling
  • Wound Healing


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