The development of systemic lupus erythematosus activity is negatively correlated with serum vitamin D levels and can complicate to osteoporosis. This systematic review aimed to synthesize the role of vitamin D supplementation in preventing osteoporosis among patients with systemic lupus erythematosus. Literature search in ScienceDirect, ProQuest journals, Scopus and SAGE journals. Studies met the following criteria were included: clinical trials reporting vitamin D use in patients with systemic lupus erythemathosus and osteoporosis. The intervention was patients receiving vitamin D. The control group was patients that did not receive vitamin D. The outcome was osteoporosis. The result show that of the 180 studies retrieved, 7 met inclusion criteria. Vitamin D supplementation increased level of 25OHD, and trabecular count. It was also associated with 13.4% reduced incidence of osteoporosis. Vitamin D supplementation was not associated with bone turnover marker. Effects on BMD, vitamin D supplementation reported a significant decrease in volumetric BMD in one study, significant increased in 2 studies, but there is study reported results that BMD did not change significantly. This systematic review demonstrated that vitamin D supplementation may prevent osteoporosis in patients with systemic lupus erythematosus through mechanisms associated with increased trabecular count and BMD but further research is needed to clarify the results.
|Number of pages||10|
|Journal||Malaysian Journal of Medicine and Health Sciences|
|Publication status||Published - Feb 2023|
- Vitamin D