The role of RANKL and OPG in alveolar bone remodeling and improvement of orthodontic tooth movement post coffee brew administration

This study was aimed at elucidating the role of RANKL and OPG in the alveolar bone remodeling and improvement of tooth movement induced by orthodontic mechanical force (OMF) post coffee brew administration. 24 rats were divided into 3 groups. Group A: the rats were administered with OMF, group B: OMF + coffee brew at 20mg / 100 g of BW in 2 ml of distilled water, and group C: OMF + caffeine of 1, 37 mg / 100 g BW in 2 ml of distilled water. OMF was conducted by ligature wires were applied on permanent maxillary right first molar and both permanent maxillary incisivus. Subsequently, the permanent maxillary right first molar was moved to mesial with closed coil spring. Observations were made on day 15 and day 22 to take GCF and measure the tooth movement on the film resulted from X-ray photograph. Coffee brew increases the levels of RANKL and OPG, and improves the movement of the teeth, therefore it may be an alternative to accelerate orthodontic treatment.