TY - JOUR
T1 - The role of probiotics in the treatment of adult atopic dermatitis
T2 - a meta-analysis of randomized controlled trials
AU - Umborowati, Menul Ayu
AU - Damayanti, Damayanti
AU - Anggraeni, Sylvia
AU - Endaryanto, Anang
AU - Surono, Ingrid S.
AU - Effendy, Isaak
AU - Prakoeswa, Cita Rosita Sigit
N1 - Funding Information:
We gratefully thank the Universitas Airlangga grant for funding and supporting this research.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Background: Atopic dermatitis (AD) is chronic inflammatory skin disease that is relapsing and a serious condition that disrupts the quality of life of affected individuals. Probiotics are an immunomodulator that can enhance the immune control of atopic dermatitis. Methods: All randomized controlled trials of probiotics for the treatment of adult AD published before December 2020 were included in this study from the PubMed databases and manual searching. Results: Six randomized controlled trials (n = 241) were selected for this meta-analysis study. Probiotics were effective in treating adult patients with AD, indicated by the decrease in Scoring Atopic Dermatitis/SCORAD (Mean Difference (MD) − 7.90, 95% CI − 7.25 to − 6.92; p < 0.00001; I2 = 96%) and improved quality of life (MD − 7.68, 95% CI − 14.08 to − 1.29; p = 0.02; I2 = 47%) which were statistically significant. However, skin severity, itch severity, Dermatology Life Quality Index (DLQI), IL-4, TFN-γ, and IgE showed no significant difference in this meta-analysis study (p > 0.05). Limitations: The study found no available data for side effects of probiotics. Strength: This meta-analysis analyzed a total of 241 AD patients of Asian and European origin. Conclusion: The use of probiotics decreased SCORAD significantly in adult patients with AD. Probiotics can improve the quality of life of patients with AD. Capsule summary: The use of probiotics in atopic dermatitis has been widely studied, with controversial results. This meta-analysis suggests that the use of probiotics can improve SCORAD and the quality of life of patients with atopic dermatitis.
AB - Background: Atopic dermatitis (AD) is chronic inflammatory skin disease that is relapsing and a serious condition that disrupts the quality of life of affected individuals. Probiotics are an immunomodulator that can enhance the immune control of atopic dermatitis. Methods: All randomized controlled trials of probiotics for the treatment of adult AD published before December 2020 were included in this study from the PubMed databases and manual searching. Results: Six randomized controlled trials (n = 241) were selected for this meta-analysis study. Probiotics were effective in treating adult patients with AD, indicated by the decrease in Scoring Atopic Dermatitis/SCORAD (Mean Difference (MD) − 7.90, 95% CI − 7.25 to − 6.92; p < 0.00001; I2 = 96%) and improved quality of life (MD − 7.68, 95% CI − 14.08 to − 1.29; p = 0.02; I2 = 47%) which were statistically significant. However, skin severity, itch severity, Dermatology Life Quality Index (DLQI), IL-4, TFN-γ, and IgE showed no significant difference in this meta-analysis study (p > 0.05). Limitations: The study found no available data for side effects of probiotics. Strength: This meta-analysis analyzed a total of 241 AD patients of Asian and European origin. Conclusion: The use of probiotics decreased SCORAD significantly in adult patients with AD. Probiotics can improve the quality of life of patients with AD. Capsule summary: The use of probiotics in atopic dermatitis has been widely studied, with controversial results. This meta-analysis suggests that the use of probiotics can improve SCORAD and the quality of life of patients with atopic dermatitis.
KW - Atopic dermatitis
KW - Human and health
KW - Probiotic
KW - Quality of life
KW - SCORAD
UR - http://www.scopus.com/inward/record.url?scp=85135984306&partnerID=8YFLogxK
U2 - 10.1186/s41043-022-00318-6
DO - 10.1186/s41043-022-00318-6
M3 - Review article
C2 - 35978397
AN - SCOPUS:85135984306
SN - 1606-0997
VL - 41
JO - Journal of Health, Population and Nutrition
JF - Journal of Health, Population and Nutrition
IS - 1
M1 - 37
ER -