TY - JOUR
T1 - The role of Moringa Oleifera L. leaves extract in increasing caspase 3 expressions in carcinoma of oral squamous cells
AU - Pertami, Sawitri Dwi Indah
AU - Budhy, Theresia Indah
N1 - Publisher Copyright:
© 2021 UPM Press. All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - Introduction: Oral cancer also affects the oral epithelial tissue, known as the carcinoma of oral squamous cells. Moringa oleifera L leaves (MOL) is an alternative herbal medicine for use as an anticancer agent. The purpose of this study is to ascertain the function of Moringa oleifera L. Leaves extract to increase caspase 3 expressions in carsinoma of oral squamous cell. Methods: This study used 25 Rattus norvegicus that were randomly divided into five groups;K-(not given MOL extract and benzopyrene),K+(benzopyrene exposed and untreated), P1 (benzopyrene exposed and given MOL extract of 3,125%), P2(benzopyrene exposed and given MOL extract of 6,25%), P3 (benzopyrene exposed and given MOL extract of 9,375%). The caspase3 expression was obtained by immunohistochemistry techniques. The data were analyzed statistically with the One way Anova and Least Significance Difference(LSD) test. Results: One way anova test showed there was a significance difference of Caspase3 expression (p=0.000) between the groups. LSD test showed that P3 group has the most significant increased of caspase3 expressions. Conclusions: Moringa oleifera L.leaves extract with an optimum concentration of 9.375 percent could increase Caspase 3 expressions in oral squamous cell carcinoma.
AB - Introduction: Oral cancer also affects the oral epithelial tissue, known as the carcinoma of oral squamous cells. Moringa oleifera L leaves (MOL) is an alternative herbal medicine for use as an anticancer agent. The purpose of this study is to ascertain the function of Moringa oleifera L. Leaves extract to increase caspase 3 expressions in carsinoma of oral squamous cell. Methods: This study used 25 Rattus norvegicus that were randomly divided into five groups;K-(not given MOL extract and benzopyrene),K+(benzopyrene exposed and untreated), P1 (benzopyrene exposed and given MOL extract of 3,125%), P2(benzopyrene exposed and given MOL extract of 6,25%), P3 (benzopyrene exposed and given MOL extract of 9,375%). The caspase3 expression was obtained by immunohistochemistry techniques. The data were analyzed statistically with the One way Anova and Least Significance Difference(LSD) test. Results: One way anova test showed there was a significance difference of Caspase3 expression (p=0.000) between the groups. LSD test showed that P3 group has the most significant increased of caspase3 expressions. Conclusions: Moringa oleifera L.leaves extract with an optimum concentration of 9.375 percent could increase Caspase 3 expressions in oral squamous cell carcinoma.
KW - Caspase3
KW - Moringa oleifera L.
KW - Oral squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85107081120&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85107081120
SN - 1675-8544
VL - 17
SP - 95
EP - 98
JO - Malaysian Journal of Medicine and Health Sciences
JF - Malaysian Journal of Medicine and Health Sciences
ER -