TY - JOUR
T1 - The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy
AU - Budi, Hendrik Setia
AU - Younus, Laith A.
AU - Lafta, Methaq Hadi
AU - Parveen, Sameena
AU - Mohammad, Hawraa Jabbar
AU - Al-qaim, Zahraa Haleem
AU - Jawad, Mohammed Abed
AU - Parra, Rosario Mireya Romero
AU - Mustafa, Yasser Fakri
AU - Alhachami, Firas Rahi
AU - Karampoor, Sajad
AU - Mirzaei, Rasoul
N1 - Publisher Copyright:
Copyright © 2023 Budi, Younus, Lafta, Parveen, Mohammad, Al-qaim, Jawad, Parra, Mustafa, Alhachami, Karampoor and Mirzaei.
PY - 2023/1/19
Y1 - 2023/1/19
N2 - A growing body of evidence has revealed that microRNA (miRNA) expression is dysregulated in cancer, and they can act as either oncogenes or suppressors under certain conditions. Furthermore, some studies have discovered that miRNAs play a role in cancer cell drug resistance by targeting drug-resistance-related genes or influencing genes involved in cell proliferation, cell cycle, and apoptosis. In this regard, the abnormal expression of miRNA-128 (miR-128) has been found in various human malignancies, and its verified target genes are essential in cancer-related processes, including apoptosis, cell propagation, and differentiation. This review will discuss the functions and processes of miR-128 in multiple cancer types. Furthermore, the possible involvement of miR-128 in cancer drug resistance and tumor immunotherapeutic will be addressed.
AB - A growing body of evidence has revealed that microRNA (miRNA) expression is dysregulated in cancer, and they can act as either oncogenes or suppressors under certain conditions. Furthermore, some studies have discovered that miRNAs play a role in cancer cell drug resistance by targeting drug-resistance-related genes or influencing genes involved in cell proliferation, cell cycle, and apoptosis. In this regard, the abnormal expression of miRNA-128 (miR-128) has been found in various human malignancies, and its verified target genes are essential in cancer-related processes, including apoptosis, cell propagation, and differentiation. This review will discuss the functions and processes of miR-128 in multiple cancer types. Furthermore, the possible involvement of miR-128 in cancer drug resistance and tumor immunotherapeutic will be addressed.
KW - cancer progression
KW - cancer suppression
KW - chemoresistance
KW - immunotherapy
KW - miR-128
UR - http://www.scopus.com/inward/record.url?scp=85147987567&partnerID=8YFLogxK
U2 - 10.3389/fonc.2022.1067974
DO - 10.3389/fonc.2022.1067974
M3 - Review article
AN - SCOPUS:85147987567
SN - 2234-943X
VL - 12
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 1067974
ER -
