The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy

Hendrik Setia Budi, Laith A. Younus, Methaq Hadi Lafta, Sameena Parveen, Hawraa Jabbar Mohammad, Zahraa Haleem Al-qaim, Mohammed Abed Jawad, Rosario Mireya Romero Parra, Yasser Fakri Mustafa, Firas Rahi Alhachami, Sajad Karampoor, Rasoul Mirzaei

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

A growing body of evidence has revealed that microRNA (miRNA) expression is dysregulated in cancer, and they can act as either oncogenes or suppressors under certain conditions. Furthermore, some studies have discovered that miRNAs play a role in cancer cell drug resistance by targeting drug-resistance-related genes or influencing genes involved in cell proliferation, cell cycle, and apoptosis. In this regard, the abnormal expression of miRNA-128 (miR-128) has been found in various human malignancies, and its verified target genes are essential in cancer-related processes, including apoptosis, cell propagation, and differentiation. This review will discuss the functions and processes of miR-128 in multiple cancer types. Furthermore, the possible involvement of miR-128 in cancer drug resistance and tumor immunotherapeutic will be addressed.

Original languageEnglish
Article number1067974
JournalFrontiers in Oncology
Volume12
DOIs
Publication statusPublished - 19 Jan 2023

Keywords

  • cancer progression
  • cancer suppression
  • chemoresistance
  • immunotherapy
  • miR-128

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