The role of micro-RNA (miRNA) 126 on diabetic macular edema. Literature review

Diabetic macular edema (DME), a further complication of diabetic retinopathy, is a clinical manifestation of a breakdown of the blood-retinal barrier in the form of thickening of the retinal fovea, exudates formation on the retina, and cystoid macular edema. The breakdown mechanism is based on the process of unstabilized vascular integrity, angiogenesis, and inflammation. A combination of these mechanisms, among others, is well known to be implemented by VEGF. Micro RNA (miRNA / miR) with its pleiotropic nature is an attractive alternative strategic therapy, especially in diseases with a multifactorial origin and its effective therapy has not been found. Micro RNA 126 which has a variety of pleiotropically targeted genes, cell, and organ functions, and approaches the retinal barrier breakdownmechanism,actsasanattractivecandidate for initiation and completion of future trials.