1 Citation (Scopus)


Periodontitis is an inflammatory disease of tooth supporting tissue caused by specific microorganisms, one of which is the bacteria Porphyromonas gingivalis (P. gingivalis). Based on the Basic Health Research (RISKESDAS) in 2018, dental and mouth problems reached 57.6% in Indonesia and only 10.2% had received services from medical personnel. In pregnancy there are hormonal changes that can affect periodontal tissue. Increasing the number of macrophages in pregnancies with chronic periodontitis can lead to a risk of preeclampsia. The aim of this study is toprove that pregnant mice with chronic periodontitis can increase the number of macrophages as a risk of pre-eclampsia. Thirty females Rattus novergicus, weighing 250-300 g with age 5-6 months, divided into 3 groups, consisting of 1 control group and 2 treatment groups. The control group is only pregnant mice. In treatment group 1 is the group of pregnant rats with chronic periodontitis and in treatment group 2 is the group of rats with chronic periodontitis. P. gingivalis ATCC 33277 was injected locally 0.03ml with a concentration of 1×109 CFU/ml under the incisor gingival sulcus in the right and left mesials. Data on the number of macrophages were analyzed using Kolmogorov-Smirnov and One-Way Anova. There were significant differences in the mean number of macrophages between groups.

Original languageEnglish
Pages (from-to)4865-4869
Number of pages5
JournalBiochemical and Cellular Archives
Issue number2
Publication statusPublished - Oct 2020


  • Macrophages
  • chronic periodontitis
  • maternal health
  • preeclampsia


Dive into the research topics of 'THE ROLE OF MACROFAGS IN PREGNANT RATS WITH CHRONIC PERIODONTITIS AS A RISK OF PREECLAMSIA'. Together they form a unique fingerprint.

Cite this