TY - JOUR
T1 - The role of EMMPRIN in perirenal fat invasion clear cell renal cell carcinoma
AU - Ramadhani, Vira Yasmina
AU - Rahaju, Anny Setijo
AU - Kurniasari, Nila
N1 - Publisher Copyright:
© 2021, Institute of Medico-Legal Publications. All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Renal Cell Carcinoma (RCC) is a common malignancy of the kidney, and Clear Cell Renal Cell Carcinoma (CCRCC) is the most common type. Accurate prediction of prognosis is valuable for therapy and follow up. EMMPRIN is a transmembrane protein of the immunoglobulin family and is associated with tumour proliferation, invasion and metastasis. This study aims to prove the role of EMMPRIN in perirenal fat invasion CCRCC. This analytic observational study with a cross-sectional approach conducted in Anatomical Pathology Institute of Dr. Soetomo Hospital, Surabaya that used 44 samples of paraffin blocks from radical nephrectomy preparations for CCRCC patients at the period of January 2013-December 2018, which were divided based on perirenal fat invasion status. The analyzed was using Spearman test. EMMPRIN expression is positively correlated with perirenal fat invasiveness (p = 0.019) in clear cell renal cell carcinoma. EMMPRIN expression is related with perirenal fat invasiveness, in clear cell renal cell carcinoma.
AB - Renal Cell Carcinoma (RCC) is a common malignancy of the kidney, and Clear Cell Renal Cell Carcinoma (CCRCC) is the most common type. Accurate prediction of prognosis is valuable for therapy and follow up. EMMPRIN is a transmembrane protein of the immunoglobulin family and is associated with tumour proliferation, invasion and metastasis. This study aims to prove the role of EMMPRIN in perirenal fat invasion CCRCC. This analytic observational study with a cross-sectional approach conducted in Anatomical Pathology Institute of Dr. Soetomo Hospital, Surabaya that used 44 samples of paraffin blocks from radical nephrectomy preparations for CCRCC patients at the period of January 2013-December 2018, which were divided based on perirenal fat invasion status. The analyzed was using Spearman test. EMMPRIN expression is positively correlated with perirenal fat invasiveness (p = 0.019) in clear cell renal cell carcinoma. EMMPRIN expression is related with perirenal fat invasiveness, in clear cell renal cell carcinoma.
KW - Clear cell renal cell carcinoma
KW - EMMPRIN
KW - Perirenal fat invasion
UR - http://www.scopus.com/inward/record.url?scp=85099929125&partnerID=8YFLogxK
U2 - 10.37506/ijfmt.v15i1.13645
DO - 10.37506/ijfmt.v15i1.13645
M3 - Article
AN - SCOPUS:85099929125
SN - 0973-9122
VL - 15
SP - 1633
EP - 1639
JO - Indian Journal of Forensic Medicine and Toxicology
JF - Indian Journal of Forensic Medicine and Toxicology
IS - 1
ER -