Background: Many studies over the world perform to find the best drugs for brain protection, but so far the result still inconsistent. The objective of this study is to evaluate the role of dexmedetomidine as brain protector based on cortisol, IL-6 and COX-2 plasma concentration. Methods: A laboratory experimental study with randomized control trial design had been conducted on 24 male, 3 month wistar rat, receive standard artificial brain trauma. Wistar rat divided into three group, K1 (NaCl), P (treatment) and K2 (control). Rat anesthetized with ketamin 80 mg/lgBW intra peritoneally, followed by artificial brain trauma for group K1 and P, after skin stitch group K1 receive saline intra peritoneal, and group P get dexmedetomidine 60 µgr/kgBW. K2 group as control group were not received any trauma nor medication. Dexmedetomidine or saline was given serially at 3 hours, 12 hours and 24 hours after trauma. Blood for ELISA analysis taken at pre-trauma, 12 hours and 24 hours after trauma. Result: Cortisol were unsignifficantly increased in K1, 12 hours after trauma compared to P group. IL-6 concentration in K1 increase significantly 12 and 24 hours after trauma. (160±15,57) vs (140,5±17,65) and (172,6±19,07) vs (124,2±23,6). Cox-2 concentration in K1 increase significantly 12 and 24 hours after trauma. (1491,41±341) vs (803,62±215,73) and (1048,45±170,43) vs (588,93±198,57.). Spearman’s analisys showed positive correlation between IL-6 and cortisol (ρ=0,83), IL-6 and COX-2 (ρ=0,71), COX-2 and cortisol (ρ=0,71) 12 hour after trauma. Conclusion: Dexmedetomidine has brain protection effect through decreasing of IL-6, cortisol and COX-2 concentration.
|Number of pages||7|
|Journal||Pakistan Journal of Medical and Health Sciences|
|Publication status||Published - 1 Jul 2018|
- Brain protection