TY - JOUR
T1 - The role of acute stress on the sensation and taste cells structure integrity through interleukin-10 and tumor necrosis factor signaling
AU - Ari, Muhammad Dimas Aditya
AU - Sunariani, Jenny
N1 - Publisher Copyright:
© 2020 Connect Journal.
PY - 2020
Y1 - 2020
N2 - Stress is an imbalance condition between expectation and reality received by human. Stress lead to increase level of cortisol in human body. As a respond an innate immunity, cortisol plays a biphasic role in inflammatory condition, as an inflammatory as well as anti-inflammatory agent. In taste receptor cell, taste cells are equipped with various immune mechanisms to challenge the destructive agents. Taste buds will lead the inflammation process by expressed the pro-inflammation cytokines like Tumor Necrosis Factor (TNF), in other hand decrease theespression of anti-inflammatory cytokines like Interleukin-10 (IL-1). This upregulation, will affect the stability and cell integrity, as TNF role to activated apoptosis signal, programmed death cell pathway. Meanwhile, disrupted stability and cell integrity will involve quantity and quality of taste buds, as result disorder of taste sensation.
AB - Stress is an imbalance condition between expectation and reality received by human. Stress lead to increase level of cortisol in human body. As a respond an innate immunity, cortisol plays a biphasic role in inflammatory condition, as an inflammatory as well as anti-inflammatory agent. In taste receptor cell, taste cells are equipped with various immune mechanisms to challenge the destructive agents. Taste buds will lead the inflammation process by expressed the pro-inflammation cytokines like Tumor Necrosis Factor (TNF), in other hand decrease theespression of anti-inflammatory cytokines like Interleukin-10 (IL-1). This upregulation, will affect the stability and cell integrity, as TNF role to activated apoptosis signal, programmed death cell pathway. Meanwhile, disrupted stability and cell integrity will involve quantity and quality of taste buds, as result disorder of taste sensation.
KW - Cortisol
KW - IL-10
KW - Mental well being
KW - TNF
KW - Taste buds
UR - http://www.scopus.com/inward/record.url?scp=85090597272&partnerID=8YFLogxK
U2 - 10.35124/bca.2020.20.S1.2775
DO - 10.35124/bca.2020.20.S1.2775
M3 - Review article
AN - SCOPUS:85090597272
SN - 0972-5075
VL - 20
SP - 2775
EP - 2783
JO - Biochemical and Cellular Archives
JF - Biochemical and Cellular Archives
ER -