The role of acute stress on the sensation and taste cells structure integrity through interleukin-10 and tumor necrosis factor signaling

Research output: Contribution to journalReview articlepeer-review

Abstract

Stress is an imbalance condition between expectation and reality received by human. Stress lead to increase level of cortisol in human body. As a respond an innate immunity, cortisol plays a biphasic role in inflammatory condition, as an inflammatory as well as anti-inflammatory agent. In taste receptor cell, taste cells are equipped with various immune mechanisms to challenge the destructive agents. Taste buds will lead the inflammation process by expressed the pro-inflammation cytokines like Tumor Necrosis Factor (TNF), in other hand decrease theespression of anti-inflammatory cytokines like Interleukin-10 (IL-1). This upregulation, will affect the stability and cell integrity, as TNF role to activated apoptosis signal, programmed death cell pathway. Meanwhile, disrupted stability and cell integrity will involve quantity and quality of taste buds, as result disorder of taste sensation.

Original languageEnglish
Pages (from-to)2775-2783
Number of pages9
JournalBiochemical and Cellular Archives
Volume20
DOIs
Publication statusPublished - 2020

Keywords

  • Cortisol
  • IL-10
  • Mental well being
  • Taste buds
  • TNF

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