The protective effect of capsaicin (Capsicum annum l) against the induction of aflatoxin b1 in hepatocytes: A study of liver histopathology in mice (mus musculus)

Background: Interaction bioinformatics analysis research and prediction of protein gene panel identification as a target of evaluating the effects of damage by AFB1 that induces hepatic injury¹. Capsaicin compounds are active²: 1). Activating apoptosis, 2). Inducing the cell cycle, 3). cell-regulation viability of transcription expression factors. Objective: Proving that capsaicin inhibits the expression of AKT1 and MAPK1 target proteins in mice due to the induction of AFB1 in silico and in vivo. Methods: Molecular docking (In silico) bioinformatics and hepatic lesions pathogenicity; congestion, degeneration, and necrosis (In vivo). Results: Molecular docking of Gibbs free energy is negative. Scoring synergistically inhibits the viability of the signaling pathway and prevents the occurrence of hepatic lesions. Conclusion: Capsaicin has been shown to have a protective effect against AFB-1 induction; by preventing the occurrence of hepatic lesions so that they have potential herbal medicine candidates as hepatoprotection.