The pro-inflammatory cytokine IL-Iβ alteration by deer (Rusa unicolor) antler extract on osteoarthritis rat model

Retno Widyowati, Suciati Suciati, Dewi M. Hariyadi, HSin S.I. Chang, Ngurah IPG Suryawan, Nurliana Tarigan, Irawati Sholikhah, Chrismawan Ardianto, Ahmad D. Nurhan, Ilham B. Sagitaras

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Osteoarthritis is a disease associated with articular cartilage degradation, intra-articular area inflammation, and subchondral bone replacement. Cytokine IL-1β has a prominent function in the inflammations process that passes in the joints. The 70% ethanol extracts of deer antler (250 and 500 mg/kg BW) and glucosamine sulfate (250 kg/BW) were evaluated for four weeks in reducing cytokine IL-1β to rat model OA-induced Monosodium iodoacetate. Measurements of joint diameter in rat's knee and hyperalgesia were performed on weeks 0, 1, 2, 3, 4, 5, 6, and 7. The presence of a significant difference in the stimulation thermal latency (p = 0.00) and the resulting increase in swelling of joint diameter (p = 0.00) are evidence that MIA has successfully induced the rat modeling of OA. A significant decrease in cytokine IL-Iβ levels was shown on week 3 after MIA injection (p = 0.00). Both concentrations of deer extracts significantly reduced knee joint diameter (p = 0.00), latency thermal stimulation (p = 0.00), and cytokine IL-1β levels (p = 0.00). Based on the results, it can be concluded that the 70% ethanol extract of deer antler is a potential medicine for OA therapy.

Original languageEnglish
Pages (from-to)1109-1114
Number of pages6
JournalSaudi Pharmaceutical Journal
Volume31
Issue number6
DOIs
Publication statusPublished - Jun 2023

Keywords

  • Deer antler
  • IL-Iβ
  • MIA
  • Osteoarthritis

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