Abstract
Type 2 diabetes mellitus is a disease caused by insulin resistance which will cause blood glucose levels to increase. That factor can result in an increase of proinflammatory cytokines such as TNF-a dan IL-1b which will cause the severity of the disease gets worse. Intraoral antidiabetic drugs have several side effects; therefore, it is necessary to provide probiotic supplements such as Lactobacillus casei to reduce levels of TNF-a dan IL-1b so that type 2 diabetes mellitus doesn’t get worse. These bacteria can also increase levels of anti-inflammatory cytokines such as IL-10. This study aims to learn and understand more deeply about the potential of Lactobacillus casei on TNF-a and IL-1b levels in type 2 diabetes mellitus. Diabetes mellitus type 2 is a chronic disease by the pancreas not being able to produce the hormone insulin in large quantities due to insulin resistance caused by impaired insulin secretion in pancreas. TNF-a and IL-1b is a cytokines that plays role in the body’s defense function, if cytokines produce in excess amount it will increase the inflammatory process. Lactobacillus casei is a probiotic bacterium that can be found in yoghurt, cheese, raw meat, and other food ingredients. Lactobacillus casei has the potential to reduce TNF-a dan IL-1b levels in type 2 diabetes mellitus.
Original language | English |
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Pages (from-to) | 107-110 |
Number of pages | 4 |
Journal | Research Journal of Pharmacy and Technology |
Volume | 16 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2023 |
Keywords
- Diabetes
- IL-1b
- Lactobacillus casei
- TNF-a
- Type 2 diabetes mellitus