The potential of immune response improvement through brucella abortus outer membrane protein and whole brucella abortus s19 vaccinations on white pulp diameter of lepus nigricollis

Background: Brucellosis is a disease that is still commonly found in developing and developed countries. The disease can be transmitted from animals to humans through food products made from animals. One of the efforts to control Brucellosis is by Brucella abortus S19 vaccine. However, the vaccine may still deliver the same reaction as natural Brucella infection. Safer vaccine development is carried out by using Outer Membrane Protein (OMP) from the infecting bacteria. Objective: The study was established to determine the potential of immune response enhancement after administering OMP B. abortus and whole B. abortus S19 vaccine that were observed through the white pulp diameter of Lepus nigricollis. Method: An enhancement in the immune response can be determined through measuring the white pulp diameter of L. nigricollis. The measurement data of the white pulp diameter would be analyzed by conducting one way ANOVA and Duncan statistical tests. Results: The results suggested that the measurements of white pulp diameter experienced a significant enhancement (p <0.01) in each treatment. The vaccine treatment by employing OMP B. abortus indicated the highest diameter measurement results with an average value of 553.73 µm. Conclusion: Vaccination by employing OMP B. abortus had a good potential to improve the immune response since there was a significant enhancement in the white pulp diameter of L. nigricollis.