Background: Tooth extraction is a procedure with the highest prevalence of causing alveolar bone damage. After extraction, the dimension will change. This procedure needs a balance of bone formation and resorption. Osteocytes are the most common cells in bone and have an essential role in bone formation. This study explores the effect of hydroxyapatite bovine tooth grafts on the number of osteocytes in the socket preservation process post-dental extraction. Methods: A total of 28 Wistar rats, 14 control and 14 treatment groups, were extracted on the lower left incisor. Control group with PEG without induction and treatment group with bovine tooth graft and PEG induction. On the 14th and 28th days, the rats were euthanized. Then perform histological examination with HE staining and cell counting using a light microscope Results: We found the treatment group had higher the average number of the osteocyte, which was 146.43±11.41 on 14th day and 288.14±161.91 on 28th day. There was a significant increase in osteocytes among the treatment group compared to the control (p=0.000). Conclusion: Hydroxyapatite bovine tooth graft application as dental socket preservation was proven to increase the number of osteocyte cells in the alveolar bone of Wistar rats after extraction. Bovine tooth grafts as dental socket preservation materials increased the number of osteocytes at a peak at 28 days.

Original languageEnglish
Pages (from-to)1489-1493
Number of pages5
JournalBali Medical Journal
Issue number3
Publication statusPublished - 1 Dec 2022


  • Bovine tooth graft
  • Dental Health
  • Osteocyte
  • Osteogenesis
  • regenerative dentistry


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