TY - JOUR
T1 - The inhibition effect of capsaicin extract against Staphylococcus aureus
T2 - An in vitro experimental study
AU - Setiawan, Fery
AU - Wahjuningrum, Dian Agustin
AU - Yudianto, Ahmad
AU - Radhianto, Eta
AU - Sunariani, Jenny
AU - Bhardwaj, Anuj
N1 - Publisher Copyright:
© 2021 Journal of International Oral Health.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Aim: Staphylococcus aureus can be isolated from contaminated food. A toothbrush is used daily in both planktonic and biofilm cells. No drugs are proven to be effective against S. aureus infection; since Methicillin has become resistant in the form Methicillin-Resistant S. aureus (MRSA), a search is necessarily made for active herbal compounds related to this infection. One of the herbal agents, capsaicin, has antibacterial effects as it has a composition of flavonoid, carotenoid, phenol, and efflux pump inhibitors (EPIs) activity. Previous studies have shown that capsaicin could be used as anti-S. aureus, but it has restricted diffusion. The present study was aimed to evaluate the efficacy of capsaicin as an alternative herbal substance to threat the antibiotic resistance of S. aureus. Materials and Methods: This research used a serial dilution method in isolating S. aureus both from the food sold from the side of road and ten days used toothbrush in the solid media called Blood Agar Plate (BAP). It was replicated to five times. Capsaicin was diluted from 100% to 0.78125%. These data were analyzed by one-way ANOVA. Results: The Minimal Inhibitory Concentration (MIC) to S. aureus planktonic formation was at 3.125%, whereas the MIC to biofilm formation was at 12.5% (P 0.05). Conclusion: Capsaicin extract could inhibit the growth of S. aureus (planktonic and biofilm cell). Therefore, capsaicin is an alternative herbal candidate to prevent problems related to S. aureus.
AB - Aim: Staphylococcus aureus can be isolated from contaminated food. A toothbrush is used daily in both planktonic and biofilm cells. No drugs are proven to be effective against S. aureus infection; since Methicillin has become resistant in the form Methicillin-Resistant S. aureus (MRSA), a search is necessarily made for active herbal compounds related to this infection. One of the herbal agents, capsaicin, has antibacterial effects as it has a composition of flavonoid, carotenoid, phenol, and efflux pump inhibitors (EPIs) activity. Previous studies have shown that capsaicin could be used as anti-S. aureus, but it has restricted diffusion. The present study was aimed to evaluate the efficacy of capsaicin as an alternative herbal substance to threat the antibiotic resistance of S. aureus. Materials and Methods: This research used a serial dilution method in isolating S. aureus both from the food sold from the side of road and ten days used toothbrush in the solid media called Blood Agar Plate (BAP). It was replicated to five times. Capsaicin was diluted from 100% to 0.78125%. These data were analyzed by one-way ANOVA. Results: The Minimal Inhibitory Concentration (MIC) to S. aureus planktonic formation was at 3.125%, whereas the MIC to biofilm formation was at 12.5% (P 0.05). Conclusion: Capsaicin extract could inhibit the growth of S. aureus (planktonic and biofilm cell). Therefore, capsaicin is an alternative herbal candidate to prevent problems related to S. aureus.
KW - Biofilm staphylococcus aureus
KW - Capsaicin
KW - Mrsa
KW - Sdg3 good health and well-being (infectious disease)
KW - Staphylococcus aureus planktonic
UR - http://www.scopus.com/inward/record.url?scp=85114086774&partnerID=8YFLogxK
U2 - 10.4103/JIOH.JIOH-45-21
DO - 10.4103/JIOH.JIOH-45-21
M3 - Article
AN - SCOPUS:85114086774
SN - 0976-7428
VL - 13
SP - 393
EP - 399
JO - Journal of International Oral Health
JF - Journal of International Oral Health
IS - 4
ER -
