The hedgehog signaling pathway in idiopathic pulmonary fibrosis: Resurrection time

Wiwin Is Effendi; Tatsuya Nagano

doi:10.3390/ijms23010171

The hedgehog signaling pathway in idiopathic pulmonary fibrosis: Resurrection time

Wiwin Is Effendi, Tatsuya Nagano

Faculty of Medicine

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

Abstract

The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays an essential role in controlling cell specification and proliferation, survival factors, and tissue patterning formation during embryonic development. Hh signal activity does not entirely disappear after development and may be reactivated in adulthood within tissue-injury-associated diseases, including idiopathic pulmonary fibrosis (IPF). The dysregulation of Hh-associated activating transcription factors, genomic abnormalities, and microenvironments is a co-factor that induces the initiation and progression of IPF.

Original language	English
Article number	171
Journal	International Journal of Molecular Sciences
Volume	23
Issue number	1
DOIs	https://doi.org/10.3390/ijms23010171
Publication status	Published - 1 Jan 2022

Keywords

Cell signaling
Chronic respiratory diseases
Hedgehog pathway
Idiopathic pulmonary fibrosis
Signal transduction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays an essential role in controlling cell specification and proliferation, survival factors, and tissue patterning formation during embryonic development. Hh signal activity does not entirely disappear after development and may be reactivated in adulthood within tissue-injury-associated diseases, including idiopathic pulmonary fibrosis (IPF). The dysregulation of Hh-associated activating transcription factors, genomic abnormalities, and microenvironments is a co-factor that induces the initiation and progression of IPF.",

keywords = "Cell signaling, Chronic respiratory diseases, Hedgehog pathway, Idiopathic pulmonary fibrosis, Signal transduction",

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AU - Nagano, Tatsuya

N1 - Funding Information: We would like to express our gratitude to the Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, and Universitas Airlangga Teaching Hospital, Surabaya, Indonesia. The illustrated figures were created with Biorender.com. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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N2 - The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays an essential role in controlling cell specification and proliferation, survival factors, and tissue patterning formation during embryonic development. Hh signal activity does not entirely disappear after development and may be reactivated in adulthood within tissue-injury-associated diseases, including idiopathic pulmonary fibrosis (IPF). The dysregulation of Hh-associated activating transcription factors, genomic abnormalities, and microenvironments is a co-factor that induces the initiation and progression of IPF.

AB - The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays an essential role in controlling cell specification and proliferation, survival factors, and tissue patterning formation during embryonic development. Hh signal activity does not entirely disappear after development and may be reactivated in adulthood within tissue-injury-associated diseases, including idiopathic pulmonary fibrosis (IPF). The dysregulation of Hh-associated activating transcription factors, genomic abnormalities, and microenvironments is a co-factor that induces the initiation and progression of IPF.

KW - Cell signaling

KW - Chronic respiratory diseases

KW - Hedgehog pathway

KW - Idiopathic pulmonary fibrosis

KW - Signal transduction

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DO - 10.3390/ijms23010171

M3 - Review article

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VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 1

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ER -

The hedgehog signaling pathway in idiopathic pulmonary fibrosis: Resurrection time

Abstract

Keywords

UN SDGs

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