The hedgehog signaling pathway in idiopathic pulmonary fibrosis: Resurrection time

Wiwin Is Effendi, Tatsuya Nagano

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)

Abstract

The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays an essential role in controlling cell specification and proliferation, survival factors, and tissue patterning formation during embryonic development. Hh signal activity does not entirely disappear after development and may be reactivated in adulthood within tissue-injury-associated diseases, including idiopathic pulmonary fibrosis (IPF). The dysregulation of Hh-associated activating transcription factors, genomic abnormalities, and microenvironments is a co-factor that induces the initiation and progression of IPF.

Original languageEnglish
Article number171
JournalInternational Journal of Molecular Sciences
Volume23
Issue number1
DOIs
Publication statusPublished - 1 Jan 2022

Keywords

  • Cell signaling
  • Chronic respiratory diseases
  • Hedgehog pathway
  • Idiopathic pulmonary fibrosis
  • Signal transduction

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