THE FIRST PATHOGENICITY ANALYSIS REPORT IN MICE WITH TWO H9N2 SUBTYPE AVIAN INFLUENZA VIRUSES ISOLATED FROM INDONESIA

H9N2 virus is LPAI virus, which can infect several species including humans and other mammals. This virus is also known as a donor of genetic material for emerging human pathogens. The previous study has shown that China isolated H9N2 virus exhibits multiple replication phenotypes in mice without any prior adaptation and is well adapted to its lungs and highly pathogenic, which can indicate that H9N2 virus has a prospective threat for public health after adaptation. In determining the pathogenicity of the H9N2 virus in mammals, especially in its lungs and reproductive organs, this study infected two avirulent H9N2 viruses that were originally derived from Indonesia into mice. Significantly, this study revealed that all of the viruses can reproduce without any adaptation. On the 3^rd day post-infection (dpi), the virus can be detected in the lungs. In addition, the virus can be detected in the reproductive organs on the 7^th dpi. Furthermore, these findings can help to unlock the pathogenic potential of H9N2 virus, which possibly threatens public health in the near future.