7 Citations (Scopus)


Aloe vera is an herbal plant that can stimulate osteoblast cell differentiation and accelerate alveolar bone healing. The combination of chitosan and ethanol extracted Aloe vera are potent to be suitable scaffold for bone tissue engineering. Biological activities of chitosan, however, depend on their molecular weight. The aim of this study was to synthesize and to evaluate the characteristics of chitosan-ethanol extracted Aloe vera scaffold (Ch-Av). It was divided two group: chitosan with low molecular weight-Aloe vera (ChL-Av) and chitosan with high molecular weight-Aloe vera (ChH-Av). Chitosan-Aloe vera with a ratio of 50:50 were made using freeze dry technique. Several characteristic tests were conducted, such as SEM examination, FTIR, XRD, XRF and compressive strength test. The average pore size and compressive strength of ChL-Av scaffolds were 124.85 μm and 2.21 ± 0.29 Mpa, while ChH-Av scaffolds were 94.71 μm and 0.06 ± 0.04 Mpa. Both of scaffolds had good pore interconnectivities and amorph structure. There were-OH group,-NH2 group, and C = O group characteristic absorption bands in FTIR. ChL-Av scaffolds can potentially be used for alveolar bone healing application.

Original languageEnglish
Pages (from-to)1376-1381
Number of pages6
JournalJournal of International Dental and Medical Research
Issue number4
Publication statusPublished - 2019


  • Aloe vera
  • Bone healing
  • Chitosan
  • Molecular weight
  • Scaffold


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