TY - JOUR
T1 - The extract soybean of local varieties as reduce advanced glycation end products and hemoglobin a1c in type 2 diabetes mice
AU - Christyaningsih, Juliana
AU - Taufiqurrahman,
AU - Sujono,
N1 - Publisher Copyright:
© 2018 The Authors. Published by Innovare Academic Sciences Pvt Ltd.
PY - 2018
Y1 - 2018
N2 - Objectives: Glucose and amino acids or fat in diabetic patients if were oxidized to form a compound amadori product (hemoglobin A1c [HbA1c]) and intermediate dicarbonyl that uses reactive carbonyl groups to bind with the amino acids to form advanced glycation end products (AGEs). Soybean is classified as a low index glycemic and content of polyphenol compounds are reported to have various biological activities, which are beneficial to health. Project objectives: The aim of this study was to determine the effect of extract soybean of local varieties obtained on AGEs and HbA1c. Methods: This study was a randomized pretest-posttest control group design. The amount of 28 Mus musculus Balb/C was divided into seven groups. The control group was divided four, while the test group was given extracts of three varieties of soybean, that is, Gema, Wilis, and Argomulyo at a dose equivalent to 1 g of soy/kg BW/day for 25 days. Type 2 diabetes (T2D) mice made with the administration of STZ at a dose of 55 mg/kg in mice. Results: There is a sign of differences in HbA1c levels in the group of mice, and there are different levels of AGEs, though not statistically significant in the group of mice. Conclusions: The extract soybean was a positive effect on the levels of AGEs and HbA1c in T2D mice.
AB - Objectives: Glucose and amino acids or fat in diabetic patients if were oxidized to form a compound amadori product (hemoglobin A1c [HbA1c]) and intermediate dicarbonyl that uses reactive carbonyl groups to bind with the amino acids to form advanced glycation end products (AGEs). Soybean is classified as a low index glycemic and content of polyphenol compounds are reported to have various biological activities, which are beneficial to health. Project objectives: The aim of this study was to determine the effect of extract soybean of local varieties obtained on AGEs and HbA1c. Methods: This study was a randomized pretest-posttest control group design. The amount of 28 Mus musculus Balb/C was divided into seven groups. The control group was divided four, while the test group was given extracts of three varieties of soybean, that is, Gema, Wilis, and Argomulyo at a dose equivalent to 1 g of soy/kg BW/day for 25 days. Type 2 diabetes (T2D) mice made with the administration of STZ at a dose of 55 mg/kg in mice. Results: There is a sign of differences in HbA1c levels in the group of mice, and there are different levels of AGEs, though not statistically significant in the group of mice. Conclusions: The extract soybean was a positive effect on the levels of AGEs and HbA1c in T2D mice.
KW - Advanced glycation end products
KW - Glycine max (L.) Merr
KW - Hemoglobin A1c
KW - Type 2 diabetes mice
UR - http://www.scopus.com/inward/record.url?scp=85056601321&partnerID=8YFLogxK
U2 - 10.22159/ajpcr.2018.v11i11.26513
DO - 10.22159/ajpcr.2018.v11i11.26513
M3 - Article
AN - SCOPUS:85056601321
SN - 0974-2441
VL - 11
SP - 333
EP - 336
JO - Asian Journal of Pharmaceutical and Clinical Research
JF - Asian Journal of Pharmaceutical and Clinical Research
IS - 11
ER -