TY - JOUR
T1 - The expression of TNF-α in recurrent aphthous stomatitis
T2 - A systematic review and meta-analysis
AU - Surboyo, Meircurius Dwi Condro
AU - Boedi, Rizky Merdietio
AU - Hariyani, Ninuk
AU - Santosh, Arvind Babu Rajendra
AU - Manuaba, Ida Bagus Pramana Putra
AU - Cecilia, Pamela Handy
AU - Ambarawati, I. Gusti Agung Dyah
AU - Parmadiati, Adiastuti Endah
AU - Ernawati, Diah Savitri
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/9
Y1 - 2022/9
N2 - Objective: The pathogenesis of recurrent aphthous stomatitis (RAS) is related to an increase of pro-inflammatory cytokine, namely tumor necrosis factor α (TNF-α). This cytokine plays an important role in the development of ulcer lesions, both in saliva, tissues and blood. This systematic review analyzed the differences of TNF-α in lesions, salivary and blood and can be used as a reliable method of diagnosis for RAS. Methods: A comprehensive search of PubMed, Scopus databases, Web of Science, Scielo, Google Scholar and Embase with keywords. The inclusion criteria were studies that assessed the saliva, serum, and RAS lesion, with the outcome reporting the mean of saliva, serum and tissue expression of TNF-α. The risk of bias was also assessed. Result: Healthy individuals showed significantly lower TNF-α than RAS (SMD = -1.517, 95% CI [-2.25, −0.78]). Although there is a significant difference between sample (i.e., saliva, serum) and detection type (i.e., cytometry bead array, ELISA), both methods can detect a significant difference in TNF-α between healthy individuals and RAS patients. Conclusions: The TNF-α is a useful diagnostic marker for RAS. We encourage saliva to detect changes in TNF-α during ulceration as it provides accuracy, reliability, and non-invasive procedure compared to a blood draw.
AB - Objective: The pathogenesis of recurrent aphthous stomatitis (RAS) is related to an increase of pro-inflammatory cytokine, namely tumor necrosis factor α (TNF-α). This cytokine plays an important role in the development of ulcer lesions, both in saliva, tissues and blood. This systematic review analyzed the differences of TNF-α in lesions, salivary and blood and can be used as a reliable method of diagnosis for RAS. Methods: A comprehensive search of PubMed, Scopus databases, Web of Science, Scielo, Google Scholar and Embase with keywords. The inclusion criteria were studies that assessed the saliva, serum, and RAS lesion, with the outcome reporting the mean of saliva, serum and tissue expression of TNF-α. The risk of bias was also assessed. Result: Healthy individuals showed significantly lower TNF-α than RAS (SMD = -1.517, 95% CI [-2.25, −0.78]). Although there is a significant difference between sample (i.e., saliva, serum) and detection type (i.e., cytometry bead array, ELISA), both methods can detect a significant difference in TNF-α between healthy individuals and RAS patients. Conclusions: The TNF-α is a useful diagnostic marker for RAS. We encourage saliva to detect changes in TNF-α during ulceration as it provides accuracy, reliability, and non-invasive procedure compared to a blood draw.
KW - Recurrent aphthous stomatitis
KW - Saliva
KW - Serum
KW - TNF-α
KW - Tissue expression
UR - http://www.scopus.com/inward/record.url?scp=85133254399&partnerID=8YFLogxK
U2 - 10.1016/j.cyto.2022.155946
DO - 10.1016/j.cyto.2022.155946
M3 - Review article
C2 - 35728503
AN - SCOPUS:85133254399
SN - 1043-4666
VL - 157
JO - Cytokine
JF - Cytokine
M1 - 155946
ER -