The effects of shiny bush (Peperomia Pellucida L. kunth) extract on fibroblast proliferation post-tooth extraction in wistar rats

R. Handhito Satriyo, Andreas Pratama Nugraha, Senitza Anisa Salsabilla, Indra Mulyawan, D. Coen Pramono, Muhammad Subhan Amir

Research output: Contribution to journalArticlepeer-review

Abstract

The dynamic healing process after tooth extraction depends on the integrity of mucoustissue and bone below the lesion. Previous studies have shown that fibroblasts play an important role in post-extractionsocket wound healingby producing the extracellular matrix and collagen fibers that support it. Herbal medicines, such as Shiny bush (Peperomia pellucida L. Kunth) are believed to accelerate the wound healing process. Flavonoids, tannins, terpenoids, carbohydrates and alkaloids, which all haveanti -inflammatory, anti -bacterial and anti-oxidant properties are found in this species. This study therefore determined the effect of herbal plants on fibroblast proliferation in the post-extraction socket healing process. Twenty-Eight Wistar rats were divided into two control and two treatment groups. Shiny Bush extract was given to the treatment group and a placebo gel was given to the control group. The amount of fibroblasts produced was calculated on the third and seventh days after tooth extraction. The number of fibroblasts in the socket after tooth extraction in the treatment group was higher as compared to the control group, both on days 3 and day 7. The use of Shiny Bush gel extract increases fibroblast proliferation, thought to play a role in the post-extraction socket healing process, as shown in wistar rats.

Original languageEnglish
Pages (from-to)4859-4862
Number of pages4
JournalBiochemical and Cellular Archives
DOIs
Publication statusPublished - 1 Dec 2019

Keywords

  • Fibroblasts proliferation
  • Shiny bush
  • Tooth extraction
  • Wound healing

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